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ABCC2

From SNPedia

is agene
is mentioned by
Full nameATP-binding cassette, sub-family C (CFTR/MRP), member 2
Other namesMRP2
EntrezGene1244
PheGenI1244
VariationViewer1244
ClinVarABCC2
GeneCardsABCC2
dbSNP1244
SADR1244
HugeNav1244
wikipediaABCC2
googleABCC2
gopubmedABCC2
EVSABCC2
HEFalMpABCC2
MyGene2ABCC2
23andMeABCC2
UniProtQ92887
EnsemblENSG00000023839
OMIM601107
# SNPs23
 Max MagnitudeChromosome positionSummary
rs146405172099,811,603
rs17222547099,831,628
rs17222723099,836,239
rs2273697199,804,058
rs280440299,781,826
rs34937870099,842,094
rs374006599,845,936Patients receiving tamoxifen have shorter recurrence-free survival
rs3740066099,844,450
rs374007099,831,661
rs374007199,830,363
rs387906395099,808,231
rs387906396099,811,604
rs414839699,832,187
rs56199535099,818,820
rs71762099,782,821
rs72558199099,832,069
rs72558200099,836,125
rs72558201099,836,193
rs72558202099,845,781
rs786205465099,818,791
rs8187710099,851,537
rs86430967599,799,352
rs927344099,784,690

The multi-drug resistance associated protein gene, ABCC2, has been implicated in drug pharmacogenomic studies and also in a study of intrahepatic cholestasis of pregnancy. In this latter case the SNP involved is rs3740066.

Another study has implicated ABCC2 SNP rs3740065 with risk for breast cancer recurrence in patients taking tamoxifen.[PMID 20124171]

Several SNPs are involved in Dubin-Johnson syndrome.