ACKR1 is the approved gene symbol for DARC, the Duffy Antigen Receptor for Chemokines.
It encodes for the Duffy blood group antigen, also called Fy glycoprotein (FY) or CD234 (Cluster of Differentiation 234). Their are 4 codominant alleles: FY*A, FY*B, FY*X and FY*Fy, that result in the common phenotypes: Fy(a+b+), Fy(a+b-), and Fy(a-b+).
Duffy antigens have many significant clinical roles. Infection resistance is one, malaria is the most noted, but there are important autoimmunity effects.
rs2814778 is a polymorphism in Duffy status, connected to geography and health outcomes.