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ACKR1

From SNPedia

is agene
is mentioned by
Full nameatypical chemokine receptor 1 (Duffy blood group)
Other namesDARC
EntrezGene2532
PheGenI2532
VariationViewer2532
ClinVarACKR1
dbSNP2532
SADR2532
HugeNav2532
wikipediaACKR1
googleACKR1
gopubmedACKR1
EVSACKR1
HEFalMpACKR1
MyGene2ACKR1
23andMeACKR1
UniProtQ16570
EnsemblENSG00000213088
OMIM613665
# SNPs5
 Max MagnitudeChromosome positionSummary
rs120750159,205,564
rs139620159,205,737
rs28147781159,204,893
rs345990822159,205,704
rs5877765070159,205,725

ACKR1 is the approved gene symbol for DARC, the Duffy Antigen Receptor for Chemokines.

It encodes for the Duffy blood group antigen, also called Fy glycoprotein (FY) or CD234 (Cluster of Differentiation 234). Their are 4 codominant alleles: FY*A, FY*B, FY*X and FY*Fy, that result in the common phenotypes: Fy(a+b+), Fy(a+b-), and Fy(a-b+).

Duffy antigens have many significant clinical roles. Infection resistance is one, malaria is the most noted, but there are important autoimmunity effects.

rs2814778 is a polymorphism in Duffy status, connected to geography and health outcomes.