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ADCY2

From SNPedia

is agene
is mentioned by
Full nameadenylate cyclase 2 (brain)
EntrezGene108
PheGenI108
VariationViewer108
ClinVarADCY2
dbSNP108
SADR108
HugeNav108
wikipediaADCY2
googleADCY2
gopubmedADCY2
EVSADCY2
HEFalMpADCY2
MyGene2ADCY2
23andMeADCY2
UniProtQ08462
EnsemblENSG00000078295
OMIM103071
# SNPs11
 Max MagnitudeChromosome positionSummary
rs100381967,517,305
rs131663607,520,768Bipolar Disorder
rs131742527,530,818
rs178268167,519,185
rs18466817,530,628
rs19464687,617,119
rs29142957,652,721
rs32615507,816,532
rs47024737,528,445
rs47024847,649,747
rs68809567,530,211

ADCY2 encodes an isoform of the adenylate cyclase gene. Adenylate cyclase is an integral membrane signaling enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP). cAMP is a secondary messenger that activates the protein kinase A (PKA) pathways that lead to changes in cellular metabolism and gene transcription patterns. ADCY2 is uniquely expressed in the brain.

Adenylate cyclases are activated downstream of G protein coupled receptors (GPCRs) through heterotrimeric G protein signaling. Many GPCRs are implicated in neuropsychiatric disorders, and many psychiatric drugs target multiple receptors at once. ADCY2 is a signal integrator of GPCR signaling in the brain.