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APP

From SNPedia

is agene
is mentioned by
Full nameamyloid beta (A4) precursor protein
EntrezGene351
PheGenI351
VariationViewer351
ClinVarAPP
GeneCardsAPP
dbSNP351
SADR351
HugeNav351
wikipediaAmyloid_precursor_protein
googleAPP
gopubmedAPP
EVSAPP
HEFalMpAPP
MyGene2APP
23andMeAPP
UniProtP05067
EnsemblENSG00000142192
OMIM104760
# SNPs22
 Max MagnitudeChromosome positionSummary
rs193922916525,897,619
rs21448425,881,968
rs281865161025,897,626
rs36404826,171,723
rs46643326,171,645
rs46644826,171,790
rs63749810025,891,853
rs63749964025,891,783
rs63750066025,891,796
rs63750264025,891,784
rs63750363025,897,642
rs63750399025,891,787
rs63750445027,269,939
rs63750579025,891,856
rs63750643025,891,793
rs63750671025,891,858
rs63750734025,891,790
rs63750847425,897,620Alzheimer's related, 1% geno is good
rs63750921025,891,820
rs63750973025,891,792
rs63751039025,891,855
rs63751263027,269,938

10.1126/science.1168979 ?-Amyloid precursor protein (APP) mutations cause familial Alzheimer's disease with nearly complete penetrance. We found an APP mutation alanine-673->valine-673 (A673V) that causes disease only in the homozygous state, whereas heterozygous carriers were unaffected, consistent with a recessive Mendelian trait of inheritance.

http://blog.personalgenomes.org/2012/08/01/the-predominant-variant-of-the-app-gene-greatly-increases-risk-for-alzheimers-disease-and-cognitive-decline/

rs63750847 according to http://www.ncbi.nlm.nih.gov/sites/varvu?gene=351