Antidepressants
From SNPedia
For a description of the different classes of antidepressants, see the Wikipedia entry.
This article reports that SNPs can be used to predict whether norepinephrine reuptake inhibitors (NRIs), such as bupropion, or selective serotinin reuptake inhibitors (SSRIs, such as Paxil) will be more effective for a particular late-life major depression patient.
Common examples of tricyclic antidepressants are imipramine (brand names Tofranil, Janimine), amitriptyline, nortriptyline (Aventyl, Pamelor), desipramine (Norpramin, Pertofrane), and clomipramine (Anafranil). Tricyclic antidepressants are poorly metabolized by individuals homozygous for poorly metabolizing CYP2D6 alleles (such as CYP2D6*4, i.e. SNP rs3892097), who will therefore generally do better at lower doses of these drugs. [PMID 18070221]
For SNPedia examples, see:
SNPs that influence how well a patient responds to certain antidepressants include:
