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CASP8

From SNPedia

is agene
is mentioned by
Full namecaspase 8, apoptosis-related cysteine peptidase
EntrezGene841
PheGenI841
VariationViewer841
ClinVarCASP8
GeneCardsCASP8
dbSNP841
SADR841
HugeNav841
wikipediaCASP8
googleCASP8
gopubmedCASP8
EVSCASP8
HEFalMpCASP8
MyGene2CASP8
23andMeCASP8
UniProtQ14790
EnsemblENSG00000064012
OMIM601763
# SNPs20
 Max MagnitudeChromosome positionSummary
rs1035140201,287,768
rs10454852201,284,866
rs113686495201,258,757
rs12990906201,249,901
rs13113201,287,439modifies risk of lymphoma
rs178604240201,276,908
rs20378150201,236,992
rs36043647201,277,115
rs3769818201,286,440
rs3769821201,258,707
rs3769823201,258,272
rs3769825201,246,657
rs3769827201,237,962
rs38175780201,271,872
rs3834129201,232,809
rs5877766650201,285,241
rs59308963201,258,757
rs67046880201,241,309
rs6723097201,263,895
rs6736233201,254,251

[1] A SNP in this gene may reduce the risk of Breast cancer.

rs1045485(C,C) individuals, in this case of European descent, have been reported to be at 40% lower risk of developing breast cancer compared to rs1045485(G,G) individuals [PMID 15601643, PMID 17018785, PMID 17293864]

Another SNP in CASP8, rs17468277, may also affect risk of breast cancer. [PMID 17293864]

[PMID 17450141] the indel (-652 6N del) is associated with multiple cancers


cancergenetics article