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DAOA

From SNPedia

is agene
is mentioned by
EntrezGene267012
PheGenI267012
VariationViewer267012
ClinVarDAOA
dbSNP267012
SADR267012
HugeNav267012
wikipediaDAOA
googleDAOA
gopubmedDAOA
EVSDAOA
HEFalMpDAOA
MyGene2DAOA
23andMeDAOA
# SNPs9
 Max MagnitudeChromosome positionSummary
rs1935062105,475,787
rs23911910105,467,097
rs3916967105,464,999
rs3916968105,475,180
rs3918341105,468,070
rs7139958105,484,383
rs778294105,489,886
rs947267105,487,313
rs9558571105,486,017


DAOA (D-amino acid oxidase activator, G72) encodes a protein which is thought to interact with D-amino oxidase (DAO), a protein that degrades D-amino acids. As one of DAOs target molecules is D-serine, an native activator of NMDA receptors, DAOA may have an effect on NMDA-based neurotransmission.

[PMID 18023149] meta-analysis of prior schizophrenia (4304 cases, 5243 controls, and 1384 families) and bipolar disorder (1145 cases, 1829 controls, and 174 families) studies, M18/rs947267(C) (OR 0.71, 95% CI 0.62-0.83) and M22/rs778293(A) (OR 0.81, 95% CI 0.72–0.91) showed association with schizophrenia in Asians, M24/rs1421292(T) (OR 1.12, 95% CI 1.01–1.24) showed association with schizophrenia in Europeans, no single marker showed association with bipolar disorder