Depression
From SNPedia
For a fine introduction to clinical depression, see Wikipedia's entry. Note that there are distinct types of depression, and studies of genetic influences typically focus on one type.
SNPs may play a role in predisposing an individual to depression and also in how patients respond to anti-depressant medications.
SNPs potentially predisposing individuals to depression include (in no particular order):
- rs729861, in the PDE9A gene [PMID 17008408]
- rs3770018, in the PDE11A gene [PMID 17008408]
- rs1801133, in the MTHFR gene PMID 12796225, PMID 16402130]
- rs1824024, in the CHRM2 gene [PMID 15229186]
- rs2061174, also in the CHRM2 gene, [PMID 15229186]
- rs1799913, in the TPH1 gene [PMID 16165107]
- rs7933505, also in the TPH1 gene [PMID 16165107]
- A '1463G-A' SNP in the TPH2 gene known as "R441H" that has no dbSNP rs# [PMID 15629698]
- Six SNPs in the BCR gene are reported to correlate with depression in a Japanese population [PMID 15866548]
- A SNP in the choline acetyltransferase (CHAT) gene [PMID 18603262]
SNPs potentially influencing how patients respond to anti-depressant medications include:
- rs1360780, in the FKBP5 gene, also influencing risk [PMID 15565110]
- rs1549870, in the PDE1A gene, with respect to desipramine or fluoxetine [PMID 17008408]
- rs1880916, in the PDE11A gene, with respect to desipramine or fluoxetine [PMID 17008408]
- rs7997012, in the HTR2A gene, with respect to citalopram [PMID 16642436]
- rs1954787, in the GRIK4 gene, with respect to citalopram [doi: 10.1176/appi.ajp.2007.06111790]
- CYP2D6 alleles influence risk for side effects from drugs such as venlafaxine(Effexor)
- rs4680 influences antidepressant response of paroxetine
- rs6314, in the HTR2A gene
