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From SNPedia

Effexor, the trade name for venlafaxine, is a drug used to treat depression. It is primarily metabolized by CYP2D6, and to a smaller extent, CYP3A4.

Individuals who are CYP2D6 poor metabolizers, mostly individuals with two copies from among the alleles CYP2D6*4, CYP2D6*5, and CYP2D6*6, are at risk for more side effects (p<0.005) in comparison with other patients. These side effects include gastrointestinal problems such as nausea, vomiting and diarrhea. However, the efficacy of Effexor was the same regardless of CYP2D6 genotype.[PMID 16958828]

SNPs that influence how well this drug works based on a patients genotype(s) include:

journal antipsychotics (Abilify, Risperdal, Seroquel), antidepressants (Prozac, Wellbutrin, Effexor, Paxil, Zoloft), anticonvulsants (Lamictal, Depakote, Trileptal, Klonopin, Topamax), and the stimulant (Concerta) metabolism affected by variations in CYP2C9, CYP2C19, and CYP2D6