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Epinephrine/all

From SNPedia

Synthesis[edit]

dopamine -> norepinephrine[edit]

 On chromosomeChromosome positionIn geneSummary
rs16111149133,635,081DBH
rs16111159133,635,393DBH
Rs1611115(C;C)9133,635,393DBHnormal
Rs1611115(C;T)9133,635,393DBHnormal
Rs1611115(T;T)9133,635,393DBHsomewhat more associated with impulsiveness and adult ADHD
rs2676067609133,636,672DBH
Rs267606760(G;G)9133,636,672DBHcommon in clinvar
rs748534769133,636,712DBH
Rs74853476(T;T)9133,636,712DBHcommon in clinvar
rs30253829133,637,199DBH
Rs2007153(A;A)9133,638,697DBHdecreased risk of schizophrenia in limited study
Rs2007153(A;G)9133,638,697DBHnormal risk of schizophrenia in limited study
Rs2007153(G;G)9133,638,697DBHincreased risk of schizophrenia in limited study
rs20071539133,638,697DBH
rs775768409133,639,848DBH
Rs77576840(C;C)9133,639,848DBHcommon in clinvar
Rs1108580(A;A)9133,639,992DBHcommon in clinvar
rs11085809133,639,992DBH
rs8632252449133,642,337DBH
Rs5320(G;G)9133,642,351DBHcommon in complete genomics
rs53209133,642,351DBH
rs8632252459133,643,474DBH
Rs4531(G;G)9133,644,248DBHcommon on affy axiom data
rs45319133,644,248DBH
rs25191529133,644,512DBH
Rs267606761(G;G)9133,647,854DBHcommon in clinvar
rs2676067619133,647,854DBH
rs752153319133,647,906DBH
Rs2283123(C;T)9133,650,175DBHdecreased risk of schizophrenia in limited study
Rs2283123(T;T)9133,650,175DBHdecreased risk of schizophrenia in limited study
rs22831239133,650,175DBH
Rs2283123(C;C)9133,650,175DBHnormal risk of schizophrenia in limited study
rs7393989133,651,448DBH
rs779059133,652,975DBH
rs62719133,657,152DBH
DBH-AS1
rs8632252469133,657,174DBH
DBH-AS1
rs1298829133,658,547DBH
DBH-AS1

norepinephrine -> epinephrine[edit]

 On chromosomeChromosome positionIn geneSummary
rs7733173991739,666,015TCAP
PNMT
rs1495857811739,666,063TCAP
PNMT
rs37643511739,668,086PNMT

Degradation[edit]

norepinephrine[edit]

 On chromosomeChromosome positionIn geneSummary
rs20755072219,940,569COMT
TXNRD2
rs20976032219,940,569COMT
TXNRD2
rs20209172219,941,361COMT
TXNRD2
rs7378662219,942,586COMT
TXNRD2
Rs737865(A;G)2219,942,598COMT
TXNRD2
rs7378652219,942,598COMT
TXNRD2
rs9332712219,943,884COMT
rs59938822219,950,010COMT
rs30878692219,953,984COMT
rs7406032219,957,654COMT
rs46463122219,960,814COMT
rs1656562219,961,340COMT
rs1657222219,961,490COMT
rs62692219,962,429COMT
MIR4761
Rs4633(T;T)2219,962,712COMT
MIR4761
higher risk for endometrial cancer
Rs4633(C;T)2219,962,712COMT
MIR4761
higher risk for endometrial cancer
rs46332219,962,712COMT
MIR4761
Rs4633(C;C)2219,962,712COMT
MIR4761
normal
Rs6267(G;G)2219,962,740COMT
MIR4761
common
Rs6267(G;T)2219,962,740COMT
MIR4761
None
Rs6267(T;T)2219,962,740COMT
MIR4761
None
rs62672219,962,740COMT
MIR4761
Rs740602(G;G)2219,962,745COMT
MIR4761
common in complete genomics
rs7406022219,962,745COMT
MIR4761
rs22393932219,962,905COMT
MIR4761
Rs4818(C;G)2219,963,684COMT
MIR4761
rs48182219,963,684COMT
MIR4761
Rs8192488(C;C)2219,963,714COMT
MIR4761
common in complete genomics
rs81924882219,963,714COMT
MIR4761
rs46802219,963,748COMT
MIR4761
warrior vs worrier; number of other associations
rs1656882219,963,748COMT
MIR4761
Rs4680(A;G)2219,963,748COMT
MIR4761
multiple associations, see details
Rs165688(G;G)2219,963,748COMT
MIR4761
Rs4680(G;G)2219,963,748COMT
MIR4761
(warrior) multiple associations, see details
rs178493082219,963,748COMT
MIR4761
rs4680(A;A)2219,963,748COMT
MIR4761
(worrier) advantage in memory and attention tasks
rs7692242219,964,281COMT
MIR4761
Rs769224(G;G)2219,964,281COMT
MIR4761
rs46463162219,964,609COMT
rs1657742219,965,038COMT
Rs9332377(C;C)2219,968,169COMT
ARVCF
rs93323772219,968,169COMT
ARVCF
Rs165599(G;G)2219,969,258COMT
ARVCF
May indicate increased susceptibility to schizophrenia
rs1655992219,969,258COMT
ARVCF
Rs165599(A;G)2219,969,258COMT
ARVCF
Rs165599(A;A)2219,969,258COMT
ARVCF
 On chromosomeChromosome positionIn geneSummary
rs5953210X43,654,798MAOA
rs5906883X43,667,695MAOA
rs1465107X43,678,769MAOA
rs796065312X43,683,572MAOA
rs5906957X43,688,062MAOA
rs909525X43,693,955MAOABest proxy for Warrior Gene repeats.
Rs909525(A;A)X43,693,955MAOAProbably MAOA 4 or 5 repeats: not Warrior Gene.
Rs909525(G;G)X43,693,955MAOAPerhaps MAOA 3 repeats: Warrior Gene?
Rs909525(A;G)X43,693,955MAOAProbably one Warrior Gene and one non-Warrior Gene.
rs2283725X43,700,729MAOA
rs796065311X43,731,344MAOA
rs587777457X43,731,695MAOA
Rs587777457(G;G)X43,731,695MAOAcommon in clinvar
Rs72554632(C;C)X43,731,784MAOAcommon in clinvar
Rs72554632(C;T)X43,731,784MAOACarrier for Brunner's Syndrome
Rs72554632(T;T)X43,731,784MAOApossible mental retardation
rs72554632X43,731,784MAOA
Rs6323(T;T)X43,731,789MAOAreduced MAOA activity
rs6323X43,731,789MAOAMonoamine oxidase A activity
Rs6323(G;G)X43,731,789MAOAIncreased monoamine oxidase A activity
rs3027400X43,733,516MAOA
rs2235186X43,736,181MAOA
rs2072743X43,740,274MAOA
rs979606X43,741,895MAOA
rs1137070X43,744,144MAOA
rs3027407X43,745,594MAOA
rs3027409X43,747,786MAOA
Rs3027409(T;T)X43,747,786MAOAcommon on affy axiom data
rs6609257X43,753,461MAOA
  • PNMT (conversion to epinephrine)
 On chromosomeChromosome positionIn geneSummary
rs7733173991739,666,015TCAP
PNMT
rs1495857811739,666,063TCAP
PNMT
rs37643511739,668,086PNMT

epinephrine[edit]

 On chromosomeChromosome positionIn geneSummary
rs20755072219,940,569COMT
TXNRD2
rs20976032219,940,569COMT
TXNRD2
rs20209172219,941,361COMT
TXNRD2
rs7378662219,942,586COMT
TXNRD2
Rs737865(A;G)2219,942,598COMT
TXNRD2
rs7378652219,942,598COMT
TXNRD2
rs9332712219,943,884COMT
rs59938822219,950,010COMT
rs30878692219,953,984COMT
rs7406032219,957,654COMT
rs46463122219,960,814COMT
rs1656562219,961,340COMT
rs1657222219,961,490COMT
rs62692219,962,429COMT
MIR4761
Rs4633(T;T)2219,962,712COMT
MIR4761
higher risk for endometrial cancer
Rs4633(C;T)2219,962,712COMT
MIR4761
higher risk for endometrial cancer
rs46332219,962,712COMT
MIR4761
Rs4633(C;C)2219,962,712COMT
MIR4761
normal
Rs6267(G;G)2219,962,740COMT
MIR4761
common
Rs6267(G;T)2219,962,740COMT
MIR4761
None
Rs6267(T;T)2219,962,740COMT
MIR4761
None
rs62672219,962,740COMT
MIR4761
Rs740602(G;G)2219,962,745COMT
MIR4761
common in complete genomics
rs7406022219,962,745COMT
MIR4761
rs22393932219,962,905COMT
MIR4761
Rs4818(C;G)2219,963,684COMT
MIR4761
rs48182219,963,684COMT
MIR4761
Rs8192488(C;C)2219,963,714COMT
MIR4761
common in complete genomics
rs81924882219,963,714COMT
MIR4761
rs46802219,963,748COMT
MIR4761
warrior vs worrier; number of other associations
rs1656882219,963,748COMT
MIR4761
Rs4680(A;G)2219,963,748COMT
MIR4761
multiple associations, see details
Rs165688(G;G)2219,963,748COMT
MIR4761
Rs4680(G;G)2219,963,748COMT
MIR4761
(warrior) multiple associations, see details
rs178493082219,963,748COMT
MIR4761
rs4680(A;A)2219,963,748COMT
MIR4761
(worrier) advantage in memory and attention tasks
rs7692242219,964,281COMT
MIR4761
Rs769224(G;G)2219,964,281COMT
MIR4761
rs46463162219,964,609COMT
rs1657742219,965,038COMT
Rs9332377(C;C)2219,968,169COMT
ARVCF
rs93323772219,968,169COMT
ARVCF
Rs165599(G;G)2219,969,258COMT
ARVCF
May indicate increased susceptibility to schizophrenia
rs1655992219,969,258COMT
ARVCF
Rs165599(A;G)2219,969,258COMT
ARVCF
Rs165599(A;A)2219,969,258COMT
ARVCF

Transporters[edit]

norepinephrine[edit]

 On chromosomeChromosome positionIn geneSummary
rs37517231654,286,285IRX3
rs23977711655,655,175SLC6A2
rs1689241655,655,632SLC6A2
rs22424461655,656,513SLC6A2
Rs3785143(C;C)1655,661,194SLC6A2normal risk of ADHD
Rs3785143(T;T)1655,661,194SLC6A2may be associated with ADHD
rs37851431655,661,194SLC6A2
Rs3785143(C;T)1655,661,194SLC6A2may be associated with ADHD
rs360291655,662,844SLC6A2
rs15327011655,664,115SLC6A2
rs1923031655,666,312SLC6A2
Rs734980(A;A)1655,668,637SLC6A2common in complete genomics
rs7349801655,668,637SLC6A2
Rs187715(A;A)1655,670,130SLC6A2
rs1877151655,670,130SLC6A2
rs360201655,679,176SLC6A2
Rs3785152(C;C)1655,682,638SLC6A2common in complete genomics
rs37851521655,682,638SLC6A2
rs401471655,682,928SLC6A2
rs360171655,684,906SLC6A2
rs105213291655,686,546SLC6A2
Rs3785155(G;G)1655,688,478SLC6A2
rs37851551655,688,478SLC6A2
rs44367751655,690,444SLC6A2
rs45645601655,690,852SLC6A2
rs115683241655,692,146SLC6A2
Rs11568324(C;C)1655,692,146SLC6A2common in complete genomics
rs18616471655,694,494SLC6A2
rs37851571655,695,924SLC6A2
rs55681655,696,212SLC6A2
rs15666521655,697,663SLC6A2
rs55691655,697,923SLC6A2
rs1219181261655,698,005SLC6A2
Rs121918126(G;G)1655,698,005SLC6A2common in clinvar
rs9984241655,698,034SLC6A2
rs18050671655,698,511SLC6A2
rs360091655,698,708SLC6A2
Rs5558(T;G)1655,699,647SLC6A2None
Rs5558(G;G)1655,699,647SLC6A2None
rs55581655,699,647SLC6A2
Rs5558(A;A)1655,699,647SLC6A2
Rs5558(T;T)1655,699,647SLC6A2normal
rs18008871655,699,677SLC6A2
rs80496811655,701,438SLC6A2
rs22424471655,702,000SLC6A2
rs71942561655,703,779SLC6A2
rs99301821655,707,385SLC6A2
 On chromosomeChromosome positionIn geneSummary
rs6091214310117,241,017SLC18A2
rs36338710117,244,053SLC18A2
Rs363387(T;T)10117,244,053SLC18A2
rs201558610117,262,226SLC18A2
rs36322410117,263,062SLC18A2
rs36322710117,267,055SLC18A2
rs36327610117,274,298SLC18A2

epinephrine[edit]

Adrenergic receptors[edit]

alpha1[edit]

 On chromosomeChromosome positionIn geneSummary
rs1048101826,770,511ADRA1A
rs13278849826,857,357ADRA1A
rs17426222826,860,300ADRA1A
rs4732957826,861,363ADRA1A
rs4732682826,863,376ADRA1A
rs573514826,863,764ADRA1A
rs1383914826,865,532ADRA1A
rs574584826,866,167ADRA1A
rs573542826,866,301ADRA1A
rs3808585826,866,809ADRA1A
 On chromosomeChromosome positionIn geneSummary
rs20824125159,290,781
Rs3181224(T;T)5159,313,842IL12B
rs31812245159,313,842IL12B
Rs3212227(A;C)5159,315,942IL12BSignificantly increased risk of developing cervical cancer
Rs3212227(C;C)5159,315,942IL12BSignificantly increased risk of developing cervical cancer
rs32122275159,315,942IL12B
Rs3212227(A;A)5159,315,942IL12B1.43x increased risk of developing psoriasis and psoriatic arthritis
rs32131205159,316,100IL12B
Rs3213120(G;G)5159,316,100IL12Bcommon in complete genomics
rs32131195159,316,780IL12B
Rs3213119(C;C)5159,316,780IL12B
Rs3213119(G;G)5159,316,780IL12Bcommon in complete genomics
rs115747905159,316,838IL12B
rs9197665159,320,556IL12B
rs28536945159,322,080IL12B
rs22888315159,323,005IL12B
Rs587776807(;)5159,323,098IL12Bcommon in clinvar
rs5877768075159,323,098IL12B
rs7862010065159,323,113IL12B
Rs3213094(A;A)5159,323,761IL12B0.79x risk for psoriasis
rs32130945159,323,761IL12B
Rs3213094(G;G)5159,323,761IL12B
Rs3213094(A;G)5159,323,761IL12B0.79x risk for psoriasis
rs32122205159,327,187IL12B
rs32122175159,328,122IL12B
rs10031995159,328,558IL12B
rs25468935159,328,952IL12B
rs25468905159,332,892FBXO44Associated with multiple sclerosis
Rs2546890(G;G)5159,332,892FBXO44Lower risk of multiple sclerosis
Rs2546890(A;A)5159,332,892FBXO44Higher risk of multiple sclerosis
Rs2546890(A;G)5159,332,892FBXO44Higher risk of multiple sclerosis
rs412924705159,333,192AC008697.1
rs178605085159,333,192AC008697.1
rs20303735159,920,474ADRA1B
rs68841055159,921,436ADRA1B
rs7562755159,924,453ADRA1B
rs68922825159,933,478ADRA1B
rs105158075159,937,991ADRA1B
LOC101927790
rs68883065159,940,107ADRA1B
rs131623025159,940,268ADRA1B
rs117500925159,940,964ADRA1B
 On chromosomeChromosome positionIn geneSummary
rs2236554204,221,394ADRA1D
rs1556832204,234,910ADRA1D

alpha2[edit]

 On chromosomeChromosome positionIn geneSummary
rs52167410111,075,832ADRA2A
rs180054410111,076,745ADRA2A
Rs1800544(C;C)10111,076,745ADRA2A
Rs1800544(G;G)10111,076,745ADRA2Acognitive effects?
rs1119541910111,079,610ADRA2A
Rs11195419(C;C)10111,079,610ADRA2Acommon in complete genomics
rs55366810111,079,821ADRA2A
Rs553668(T;T)10111,079,821ADRA2A
Rs553668(C;C)10111,079,821ADRA2Acommon/normal
 On chromosomeChromosome positionIn geneSummary
rs28365031296,115,249ADRA2B
rs29000568296,115,256ADRA2B
rs4066772296,115,258ADRA2B
rs786205528296,115,486ADRA2B
rs1724120296,143,592DUSP2
 On chromosomeChromosome positionIn geneSummary
rs28365031296,115,249ADRA2B
rs29000568296,115,256ADRA2B
rs4066772296,115,258ADRA2B
rs786205528296,115,486ADRA2B

beta1[edit]

 On chromosomeChromosome positionIn geneSummary
rs180125210114,044,277ADRB1
Rs1801252(A;A)10114,044,277ADRB1None
Rs1801252(A;G)10114,044,277ADRB1
Rs1801252(G;G)10114,044,277ADRB1
rs180125310114,045,297ADRB1
Rs1801253(C;C)10114,045,297ADRB1responds well to bucindolol; may also depend on rs1801252
Rs1801253(C;G)10114,045,297ADRB1
Rs1801253(G;G)10114,045,297ADRB1

beta2[edit]

 On chromosomeChromosome positionIn geneSummary
rs177782575148,825,014ADRB2
rs346230975148,825,046ADRB2
rs28957955148,825,403ADRB2
rs24007075148,825,489ADRB2
rs20530445148,825,809ADRB2
rs171088035148,825,993ADRB2
rs126547785148,826,178ADRB2
rs111680705148,826,364ADRB2
rs119594275148,826,465ADRB2
rs10427115148,826,785ADRB2
rs18017045148,826,812ADRB2
rs173342425148,826,877ADRB2
Rs1042713(A;G)5148,826,877ADRB21.3x increased risk that pediatric inhaler use may make asthma worse
Rs17334242(A;A)5148,826,877ADRB2
Rs1042713(A;A)5148,826,877ADRB21.7x increased risk that pediatric inhaler use may make asthma worse
rs10427135148,826,877ADRB2
Rs1042713(G;G)5148,826,877ADRB2normal
Rs1042714(C;C)5148,826,910ADRB2normal
rs10427145148,826,910ADRB2
Rs1042714(C;G)5148,826,910ADRB2complex; see details for increased risks
Rs1042714(G;G)5148,826,910ADRB2complex; see details for increased risks
rs10427175148,827,083ADRB2
Rs1800888(T;T)5148,827,322ADRB2increased risk of coronary artery disease
rs18008885148,827,322ADRB2
Rs1800888(C;C)5148,827,322ADRB2normal
Rs1800888(C;T)5148,827,322ADRB2increased risk of coronary artery disease
rs10427185148,827,354ADRB2
rs10427195148,827,884ADRB2

beta3[edit]

 On chromosomeChromosome positionIn geneSummary
rs4994837,966,280ADRB3
Rs4994(C;C)837,966,280ADRB32x higher risk in certain women for cardiac events
Rs4994(C;T)837,966,280ADRB32x higher risk in certain women for cardiac events
Rs4994(T;T)837,966,280ADRB3normal