Have questions? Visit https://www.reddit.com/r/SNPedia

FLG

From SNPedia

is agene
is mentioned by
Full namefilaggrin
EntrezGene2312
PheGenI2312
VariationViewer2312
ClinVarFLG
GeneCardsFLG
dbSNP2312
DiseasesFLG
SADR2312
HugeNav2312
wikipediaFLG
googleFLG
gopubmedFLG
EVSFLG
HEFalMpFLG
MyGene2FLG
23andMeFLG
UniProtP20930
EnsemblENSG00000143631
OMIM135940
# SNPs32
 Max MagnitudeChromosome positionSummary
rs114733570
rs1157463630152,312,410
rs1219096260152,307,225
rs1387264430152,307,547
rs142991475
rs1444194790152,311,957
rs1471452340152,308,647
rs148606936
rs149484917
rs1505974130152,305,146
rs199885226
rs200002200
rs2013565580152,304,661
rs2485518152,315,409
rs2786680152,325,202
rs3126065152,303,083
rs3745887910152,307,622
rs3814299152,302,977
rs3814300152,303,164
rs5582691373.9152,312,601
rs618167613.9152,313,385
rs741294470152,303,313
rs745516434
rs756998312
rs760831749
rs7640946650152,304,562
rs774129089
rs774362740
rs777181377
rs7970450900152,312,743

[PMID 16550169] - loss of function mutations in FLG, most commonly rs61816761 (R501X) or rs558269137 (2284del4), carried by ~9% of Europeans, strongly predisposed for atopic dermatitis "highly significant association with asthma occurring in the context of atopic dermatitis".

3x risk of peanut allergy http://www.cbc.ca/news/health/story/2011/03/11/peanut-allergy-gene.html

[PMID 18049447] - FLG mutations (R510X and 2284del4 genotyped) assoc. w/ nickel sensitivity and nickel sensitivity combined with jewelery intolerance, but not with other contact allergens, in a 1,502 strong subset of the KORA C study group.

considerably more information is available elsewhere. see wikipedia, a glut of PubMed-listed papers, and the FLG OMIM entry