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FLG

From SNPedia

is agene
is mentioned by
Full namefilaggrin
EntrezGene2312
PheGenI2312
VariationViewer2312
ClinVarFLG
GeneCardsFLG
dbSNP2312
SADR2312
HugeNav2312
wikipediaFLG
googleFLG
gopubmedFLG
EVSFLG
HEFalMpFLG
MyGene2FLG
23andMeFLG
UniProtP20930
EnsemblENSG00000143631
OMIM135940
# SNPs10
 Max MagnitudeChromosome positionSummary
rs1219096260152,307,225
rs1471452340152,308,647
rs2485518152,315,409
rs2786680152,325,202
rs3126065152,303,083
rs3814299152,302,977
rs3814300152,303,164
rs618167613.9152,313,385
rs741294470152,303,313
rs7970450900152,312,743

[PMID 16550169] - loss of function mutations in FLG (rs61816761( R501X and 2284del4, carried by ~9% of Europeans), strongly predisposed for atopic dermatitis "highly significant association with asthma occurring in the context of atopic dermatitis".

3x risk of peanut allergy http://www.cbc.ca/news/health/story/2011/03/11/peanut-allergy-gene.html

[PMID 18049447] - FLG mutations (R510X and 2284del4 genotyped) assoc. w/ nickel sensitivity and nickel sensitivity combined with jewelery intolerance, but not with other contact allergens, in a 1,502 strong subset of the KORA C study group.

considerably more information is available elsewhere. see wikipedia, a glut of PubMed-listed papers, and the FLG OMIM entry