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FUT3

From SNPedia

is agene
is mentioned by
Full namefucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
EntrezGene2525
PheGenI2525
VariationViewer2525
ClinVarFUT3
dbSNP2525
SADR2525
HugeNav2525
wikipediaFUT3
googleFUT3
gopubmedFUT3
EVSFUT3
HEFalMpFUT3
MyGene2FUT3
23andMeFUT3
UniProtP21217
EnsemblENSG00000171124
OMIM111100
# SNPs3
 Max MagnitudeChromosome positionSummary
rs23069695,851,790
rs2836245905,844,781
rs374563505,844,332

FUT3 or the 'Lewis gene', codes for the Fucosyltransferase-3 enzyme, Galactoside-3(4)-L-fucosyltransferase, which adds fucose to precursor oligosaccharides to synthesize the Lewis antigen. The version of Lewis antigen formed is determined by FUT2. The active form(Le) is dominant over the inactive(le). Mutations is the gene cause non-function, resulting in the Lewis-negative type. Multiple variants are known.

The Lewis antigen is needed to express CA19-9, an important biomarker used to track tumor status, primarily pancreatic cancer. In 10% of Caucasians CA19-9 is not produced.

Le status is associated with infection susceptibility.