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GAB2

From SNPedia

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Full nameGRB2-associated binding protein 2
EntrezGene9846
PheGenI9846
VariationViewer9846
ClinVarGAB2
dbSNP9846
SADR9846
HugeNav9846
wikipediaGAB2
googleGAB2
gopubmedGAB2
EVSGAB2
HEFalMpGAB2
MyGene2GAB2
23andMeGAB2
UniProtQ9UQC2
EnsemblENSG00000033327
OMIM606203
# SNPs9
 Max MagnitudeChromosome positionSummary
rs1079329478,285,357
rs1089948978,384,327
rs138560078,225,120
rs229257378,342,093
rs23731150.178,380,104
rs494526178,279,214
rs7101429278,281,921
rs710717478,286,890
rs711585078,334,025

The GAB2 gene, encoding the GRB-associated binding protein 2, has been studied for its additive effect on the risk of developing late-onset Alzheimer's disease in conjunction with carriers of ApoE4 alleles. [PMID 17553421]

A summary of the increased odds (OR) associated with each SNP is shown below, indicating the risk allele; note that these odds are only relevant to individuals who are (also) ApoE4 carriers, since the research cited did not observe any increased risk for ApoE4 non-carriers:

Note also that the increased risk for developing Alzheimer's seen in this study did not include risk for earlier age at onset.

Overall, an odds ratio of 24.6 for overall genetic risk of developing late-onset Alzheimer's is obtained when both ApoE4 and the GAB2 rs2373115 alleles are present.