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GSTM1

From SNPedia

is agene
is mentioned by
Full nameglutathione S-transferase mu 1
EntrezGene2944
PheGenI2944
VariationViewer2944
ClinVarGSTM1
dbSNP2944
SADR2944
HugeNav2944
wikipediaGSTM1
googleGSTM1
gopubmedGSTM1
EVSGSTM1
HEFalMpGSTM1
MyGene2GSTM1
23andMeGSTM1
UniProtP09488
EnsemblENSG00000134184
OMIM138350
# SNPs3
 Max MagnitudeChromosome positionSummary
rs13595560533,813,975
rs3666311.25109,709,850
rs4147565109,689,155

The GSTM1 gene encodes glutathione S-transferase M1, a member of the GST family of enzymes. These enzymes have broad detoxifying abilities against carcinogens, drugs, or other toxins.

Although there are a few SNPs in the GSTM1 gene, the main polymorphism of interest is the null allele - in other words, some individuals are lacking one or even both copies of the GSTM1 gene. Individuals with fewer copies of GSTM1 may be somewhat more prone to allergies, asthma, and certain cancers, especially if they are missing copies of other GST family genes such as GSTP1 or GSTT1.


[PMID 18303971] While testing for null alleles seems sufficient for Caucasians and Oriental subjects, the most promising target SNPs for GSTT1 association studies in African-American and Hispanic subjects may be those causing the amino acid changes Asp43Asn, Thr65Met, Thr104Pro and the single nucleotide deletion in exon 4.