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GSTP1

From SNPedia

is agene
is mentioned by
Full nameglutathione S-transferase pi 1
EntrezGene2950
PheGenI2950
VariationViewer2950
ClinVarGSTP1
GeneCardsGSTP1
dbSNP2950
SADR2950
HugeNav2950
wikipediaGSTP1
googleGSTP1
gopubmedGSTP1
EVSGSTP1
HEFalMpGSTP1
MyGene2GSTP1
23andMeGSTP1
UniProtP09211
EnsemblENSG00000084207
OMIM134660
# SNPs13
 Max MagnitudeChromosome positionSummary
rs1138272067,586,108
rs16952.167,585,218influences asthma risk
rs1759306867,583,461
rs1871042067,586,373
rs414758167,584,114
rs489167,586,499
rs659125567,582,077
rs659125667,582,428
rs749174067,585,782
rs76280367,584,785
rs8191439067,583,826
rs94789467,585,218
rs947895067,586,935

The glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalysing with reduced glutathione the conjugation of many hydrophobic and electrophilic compounds. Based on their biochemical, immunological, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The GSTP1 member of the GST family is a polymorphic gene encoding active, functionally different GSTP1 variant proteins, which are believed to function in xenobiotic metabolism, and play a role in susceptibility to cancer and other diseases.