Genos offers next-generation sequencing services to consumers. Based in San Francisco, Genos Research is a spin-off of Complete Genomics' consumer division and was founded in 2016 by two former executives of that company.
Genos is currently offering CLIA certified, 75x whole exome sequencing available for $499. This service includes:
- the ability to download your data, including in a format that is Promethease-compatible;
- interactive tools, including a browsable map of your genetic variations and personalized variant and conditions summary; and,
- access to certified genetic counselors at preferred rates.
To download your Promethease compatible data file:
- Log into your Genos Account at www.genosresearch.com
- Navigate to your Account Settings on the top right
- Select 'Data Download'
- Under 'Promethease-Compatible File,' select the 'Generate File' button to begin. This button will change to ‘Download’ once the file is generated, which may take a few minutes. You will also get an email notification when the file is ready for download
- When the download is complete, visit www.promethease.com
- Click on "Upload raw data"
- Navigate to your downloads folder on your computer and upload the zip file
Two major differences between Genos and other consumer genomics companies are the focus on next generation sequencing, and, the amount of data sequenced. Genos currently sequences an individual’s entire exome, covering ~50 million base pairs, compared to the ~1 million or less typical of microarray based providers.
Initial Promethease reports run with data provided by Genos yield ~42,000 genotypes, of which 34,000 are from ClinVar. By comparison, the most recent Ancestry ($99) and 23andMe ($99) based Promethease reports yield ~47,000 and 23,000 genotypes, with about 24,000 and 2,000 annotated in ClinVar, respectively.
A Genos core principle is that users own and control their own data and that it is never shared without their consent. Genos has said that starting in late 2016 it will enable users to share data with research partners on a study-by-study basis and to provide compensation (to users) for such sharing.
For more information about Genos Beta, visit URL: https://www.genosresearch.com/?cid=snp-100-ent.
Note: The URL provided is not an affiliate link; we receive no compensation from any clicks on it, and it's only use is to help Genos know that a visitor has come to them from SNPedia or Promethease.
The Genos service uses the Agilent SureSelect All Exon v5 kit for exome capture; our own estimates as well as published ones (,) indicate that for most genes, this technology produces ~90-95% coverage of the medically significant variants, i.e. those annotated as pathogenic in ClinVar.
Fasta formatted data files are available upon request from Genos.