Gs127
From SNPedia
| Gs127 | |
|---|---|
| Magnitude | 3 |
| Repute | |
| Summary | Intermediate warfarin metabolizer |
| Criteria | Gs127/criteria |
Approximately 30% of people are intermediate metabolizers of the popular anticoagulant Warfarin and would probably need a decreased dosage. This due to rs1799853 or rs1057910 respectively leading to the CYP2C9*2 or CYP2C9*3 alleles. For prodrugs that require activation by CYP2C9, an alternative treatment or increased dose should be considered.
See also gs126
