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From SNPedia

Magnitude 3
Summary Intermediate warfarin metabolizer
Criteria Gs127/criteria

Approximately 30% of people are intermediate metabolizers of the popular anticoagulant Warfarin and would probably need a decreased dosage. This due to rs1799853 or rs1057910 respectively leading to the CYP2C9*2 or CYP2C9*3 alleles. For prodrugs that require activation by CYP2C9, an alternative treatment or increased dose should be considered.

See also gs126