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From SNPedia

Magnitude 4
Repute Bad
Summary 3x increased risk of venous thrombosis
Criteria Gs251/criteria

Coexistence of the R2 polymorphism rs1800595 with factor V Leiden rs6025 increases the risk for venous thrombosis approximately to a 16-fold increased risk. labcorp

"Factor V HR2 Allele, DNA Mutation Analysis is useful in patients who are carriers of Factor V Mutation (Leiden). Coinheritance of Factor V Mutation (Leiden) is associated with a 3-4-fold increased risk of venous thrombosis compared to inheritance of Factor V Mutation (Leiden) alone." http://www.questdiagnostics.com/testcenter/TestDetail.action?ntc=17902