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HLA-B

From SNPedia

is agene
is mentioned by
Full namemajor histocompatibility complex, class I, B
EntrezGene3106
PheGenI3106
VariationViewer3106
ClinVarHLA-B
GeneCardsHLA-B
dbSNP3106
SADR3106
HugeNav3106
wikipediaHLA-B
googleHLA-B
gopubmedHLA-B
EVSHLA-B
HEFalMpHLA-B
MyGene2HLA-B
23andMeHLA-B
UniProtP01889
EnsemblENSG00000234745
OMIM142830
# SNPs924
 Max MagnitudeChromosome positionSummary
rs1049645031,354,145
rs1050240031,355,357
rs1050341031,355,560
rs1050368031,356,301
rs105037031,356,312
rs1050379031,356,377
rs1050388031,356,729
rs1050393031,356,742
rs1050458031,357,148
rs1050459031,357,144
rs1050462031,357,134
rs1050486031,356,925
rs1050502031,356,890
rs1050517031,356,866
rs1050518031,356,864
rs1050529031,356,838
rs1050538031,356,822
rs105054331,356,818
rs105055631,356,809
rs1050564031,356,785
rs1050570031,356,772
rs1050628031,356,375
rs1050642031,356,351
rs1050654031,356,323
rs1050683031,356,242
rs1050692031,356,214
rs1050696031,356,203
rs1050723031,355,544
rs1050747031,355,519
rs1050823031,355,426
rs1051488031,355,134
rs1053726031,354,270
rs1054111031,354,249
rs1055149031,354,181
rs1055348031,354,171
rs1055821031,354,142
rs1055849031,354,139
rs1055890031,354,138
rs105802631,353,908
rs1065378031,356,856
rs106538631,356,770
rs1065502031,355,378
rs1071652031,356,424
rs1071816031,356,759
rs1071817031,356,751
rs1093031,354,129
rs111301312031,354,331
rs1131112031,356,407
rs1131156031,357,118
rs1131159031,357,115
... further results

HLA-B is a gene/antigen in the HLA system. There are hundreds of alleles, with many similar variants grouped together, that form subtypes HLA-B*2701 to HLA-B*2763. The genotype is connected with immunity and autoimmune diseases, specifically autoimmune forms of arthritis.

Two commonly tested tag SNPs for HLA-B27 are rs13202464 and rs4349859. Another tag SNP that is sometimes tested is rs3819299.

HLA-B27 (but not HLA-B*27:09) is associated with ankylosing spondylitis, reactive arthritis, psoriasis and psoratic arthritis, inflammatory bowel disease, and acute anterior uveitis; Many individuals that carry the allele have some symptoms (especially uveitis), but most with the allele do not have ankylosing spondylitis.
See HLA-B27 Syndromes.

HLA-B51 is associated with Behçet's disease and other inflammatory joint and skin diseases.

Two associated tag SNPs for HLA-B51 are rs79556279 and rs76546355. [PMID 24821759]

HLA-B*1502, *5701, and *5801 are associated with drug reactions.

HIV: HLA-B27 or HLA-B57 progress slower, HLA-B35 faster.

HLA-B53 protects against malaria and is most common in West Africa.

Tag SNPs for HLA-B antitypes on the 1M Illumina chip[edit]

HLA SNP r2 HLA_FRQ SNP_FRQ
B*07:04 rs3104402 0.009 0.000 0.02
B*15:02 rs2395148 0.025 0.003 0.03
B*15:03 rs7742033 0.054 0.005 0.02
B*15:04 rs9391714 0.009 0.000 0.03
B*15:05 rs6903896 0.004 0.000 0.03
B*15:06 rs9500864 0.008 0.000 0.02
B*15:07 rs17493811 0.016 0.001 0.04
B*15:08 rs9357117 0.027 0.001 0.02
B*15:09 rs16899178 0.007 0.000 0.05
B*15:10 rs3093542 0.043 0.002 0.02
B*15:13 rs9357117 0.041 0.001 0.02
B*15:15 rs2021783 0.018 0.000 0.01
B*15:16 rs3218822 0.014 0.001 0.02
B*15:18 rs16899178 0.033 0.003 0.05
B*15:21 rs6902544 0.069 0.001 0.01
B*15:24 rs3895681 0.015 0.000 0.01
B*15:25 rs2859110 0.017 0.001 0.01
B*15:26 rs3763288 0.021 0.002 0.09
B*15:27 rs3817964 0.003 0.000 0.06
B*15:30 rs9405015 0.009 0.000 0.02
B*18:02 rs12662077 0.010 0.001 0.05
B*27 rs13202464 0.071 0.07
B*27:03 rs9366775 0.007 0.000 0.03
B*27:04 rs3819299 0.023 0.001 0.06
B*27:07 rs3093671 0.021 0.001 0.03
B*35:02 rs2073724 0.058 0.010 0.08
B*35:05 rs2073724 0.032 0.003 0.08
B*35:12 rs3093561 0.086 0.001 0.01
B*35:14 rs2517623 0.018 0.000 0.01
B*35:17 rs3093561 0.029 0.001 0.01
B*35:21 rs7761890 0.009 0.000 0.02
B*35:43 rs9366775 0.012 0.000 0.03
B*38:02 rs2233954 0.049 0.004 0.05
B*39:01 rs6910087 0.060 0.010 0.16
B*39:02 rs7761890 0.006 0.000 0.02
B*39:08 rs4711250 0.015 0.000 0.01
B*39:09 rs2071288 0.011 0.001 0.01
B*39:10 rs9469093 0.008 0.001 0.02
B*40:05 rs16899178 0.006 0.000 0.05
B*40:09 rs3093561 0.014 0.000 0.01
B*40:10 rs35759989 0.005 0.000 0.03
B*40:23 rs2021783 0.018 0.000 0.01
B*42:02 rs9468942 0.047 0.001 0.01
B*44:04 rs3130666 0.016 0.000 0.02
B*45:01 rs2523477 0.087 0.010 0.08
B*48:01 rs3093668 0.052 0.003 0.02
B*50:02 rs915653 0.010 0.000 0.02
B*51 rs79556279 0.057 0.06
B*51:02 rs3093561 0.038 0.001 0.01
B*51:05 rs3093665 0.021 0.000 0.02
B*51:06 rs6903896 0.017 0.001 0.03
B*51:08 rs7747738 0.017 0.001 0.03
B*54:01 rs3819284 0.077 0.002 0.02
B*56:03 rs2021783 0.018 0.000 0.01
B*56:04 rs3819284 0.019 0.000 0.02
B*57 rs2395029 0.057 0.05
B*57:02 rs9296020 0.007 0.000 0.01
B*57:03 rs9468559 0.007 0.001 0.02
B*58:02 rs6902738 0.053 0.002 0.01
B*73:01 rs2071288 0.060 0.001 0.01
B*78:01 rs7747738 0.017 0.001 0.03
B*81:01 rs9263582 0.014 0.001 0.05