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HLA-DRA

From SNPedia

is agene
is mentioned by
Full namemajor histocompatibility complex, class II, DR alpha
EntrezGene3122
PheGenI3122
VariationViewer3122
ClinVarHLA-DRA
GeneCardsHLA-DRA
dbSNP3122
SADR3122
HugeNav3122
wikipediaHLA-DRA
googleHLA-DRA
gopubmedHLA-DRA
EVSHLA-DRA
HEFalMpHLA-DRA
MyGene2HLA-DRA
23andMeHLA-DRA
UniProtP01903
EnsemblENSG00000204287
OMIM142860
# SNPs19
 Max MagnitudeChromosome positionSummary
rs104188532,445,032
rs144120198032,443,193
rs222713932,445,682
rs223980332,444,056
rs239518232,445,540
rs312987132,438,565
rs31298781.332,440,958
rs312988232,441,753
rs312988832,443,949
rs312988932,445,768
rs312989032,446,496
rs3135388232,445,274
rs3135391332,443,210
rs317792832,444,658
rs493535632,444,611
rs7192332,443,869
rs719432,444,703
rs7758128032,377,506
rs926864532,440,750


HLA-DRA codes for the alpha subunit of the HLA DR loci, and is largely invariant. The variation in HLA-DR comes from the beta units, which is important for organ compatibility.

The DRA SNP A/G rs3135388 is a proxy for the DRB1*1501 allele, which is associated with MS. Concordance between the rs3135388 A allele and DRB1*1501 was found in 2730 of 2757 subjects by the International Multiple Sclerosis Genetics Consortium (2007).