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IL1B

From SNPedia

is agene
is mentioned by
Full nameinterleukin 1, beta
EntrezGene3553
PheGenI3553
VariationViewer3553
ClinVarIL1B
GeneCardsIL1B
dbSNP3553
SADR3553
HugeNav3553
wikipediaIL1B
googleIL1B
gopubmedIL1B
EVSIL1B
HEFalMpIL1B
MyGene2IL1B
23andMeIL1B
UniProtP01584
EnsemblENSG00000125538
OMIM147720
# SNPs14
 Max MagnitudeChromosome positionSummary
rs1143623112,838,252
rs11436270112,836,810
rs1143630112,834,078
rs1143633112,832,890
rs11436340112,832,813
rs1143639112,831,216
rs1143642112,830,976
rs1143643112,830,725
rs169442112,837,290Increases susceptibility to mental illness and osteoarthritis.
rs2853550112,829,544
rs30872580112,837,294
rs3136558112,833,698
rs3917345112,837,577
rs3917356112,834,786

IL1B -511 allele heterozygotes have a 4 fold higher chance of surviving bacterial meningitis than (either) homozygote [PMID 11023482]. Odds of surviving meningitis apparently further increase 2X for IL1B -511 heterozygotes who are also rs419598(T;T), i.e. homozygous for IL1RN +2018 rs419598 (T) allele (the most common one; also known as "+8006").

There does not appear to be an rs# in dbSNP for the -511 allele.