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MCM6

From SNPedia

is agene
is mentioned by
Full nameminichromosome maintenance complex component 6
EntrezGene4175
PheGenI4175
VariationViewer4175
ClinVarMCM6
GeneCardsMCM6
dbSNP4175
SADR4175
HugeNav4175
wikipediaMCM6
googleMCM6
gopubmedMCM6
EVSMCM6
HEFalMpMCM6
MyGene2MCM6
23andMeMCM6
UniProtQ14566
EnsemblENSG00000076003
OMIM601806
# SNPs8
 Max MagnitudeChromosome positionSummary
rs145946881135,851,176
rs1825492135,859,184
rs309180135,856,685
rs3754686135,845,706
rs413803470135,851,081
rs415257470135,851,073
rs49882340135,851,103
rs49882352.5135,851,076

The MCM6 gene encodes the protein DNA replication licensing factor MCM6, one of the highly conserved minichromosome maintenance complex proteins that are essential for the initiation of eukaryotic genome replication.

MCM6 contains two of the regulatory regions for LCT, the gene encoding the protein lactase, located in two of the nearby MCM6 introns, rs182549 and rs4988235, approximately 14 kb (-13910) and 22 kb (-22018) upstream of LCT. The (-13910) region, have been shown to function in vitro as an enhancer element capable of differentially activating transcription of LCT promoter. Mutations in these regions are frequently associated with lactose tolerance into adult life.