Obesity

From SNPedia

rs16964465 and rs16964476 in the SCG3 gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion [PMID 17094264] [1].

rs16964465 and rs16964476 affected the transcriptional activity of SCG3, and subjects with the minor allele seemed to be resistant to obesity. rs3764220 significantly associated with an obesity phenotype. [2]

3 (linked) SNPs in the TUB gene influence obesity: rs1528133, rs2272382, rs2272383

rs662799 -1131T>C in APOA5 is present in approximately 13% of this population, modulates the effect of fat intake on BMI and obesity risk in both men and women. [PMID 17211608]

[PMID 17334513] The -11377 C > G adiponectin gene promoter variant is i) associated with decreased serum adiponectin levels (and therefore increased risk of obesity), ii) correlated with the presence of coronary atherosclerosis, iii) significantly predictive of vascular events among men undergoing coronary angiography.

rs6971091, a SNP in an uncharacterized gene on chromosome 7, has an OR >2 for obesity

a SNP in NPY may influence obesity wash post

rs9939609 in FTO is associated with changes in BMI and obesity from the age 7 on; similarly, rs1121980 in the FTO gene shows strong association with early onset obesity

BMI may not reflect the amount of internal fat [3]

a snp in APOA2 influences obesity

rs2229616, a variant in the MC4R gene known as V103I, has been associated with appetite regulation, body mass index (and thus obesity), and other features of metabolic syndrome.[PMID 18239646]