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PTGS2

From SNPedia
(Redirected from Ptgs2)

is agene
is mentioned by
EntrezGene5743
PheGenI5743
VariationViewer5743
ClinVarPTGS2
GeneCardsPTGS2
dbSNP5743
SADR5743
HugeNav5743
wikipediaPTGS2
googlePTGS2
gopubmedPTGS2
EVSPTGS2
HEFalMpPTGS2
MyGene2PTGS2
23andMePTGS2
# SNPs23
 Max MagnitudeChromosome positionSummary
rs133060350186,672,715
rs204150186,681,556
rs204170186,681,189
rs20426186,680,288
rs2066826186,676,795
rs22065930186,673,297
rs27455570186,680,089
rs32186250186,674,409
rs46482610186,679,872
rs46482620186,679,617
rs4648276186,676,356
rs46482980186,672,550
rs4648308186,671,485
rs46483100186,671,393
rs52700186,680,587
rs52750186,673,926
rs52760186,673,855
rs5277186,679,065
rs689462186,681,951
rs689465186,681,714
rs6894661.4186,681,619
rs6894690186,672,065
rs6894700186,671,926


PTGS2 is the inducible isozyme of prostaglandin-endoperoxide synthase, also known as cyclooxygenase. It has been linked to numerous conditions, especially involving inflammation or cancer. Also known as COX2.

[PMID 17479405] Haplotypes A-1195G-765T8473 and A-1195C-765T8473 variants of COX-2 were associated with 1.3X increased risk of breast cancer in a Chinese population

[PMID 16361272] Relative to individuals with a PTGS2 Ex10 +837 TT genotype, those carrying the C allele (TC or CC genotype) had a 1.8-fold risk of bile duct cancer in a Chinese population

[PMID 12920574] In a group of Pima Indians, individuals with the variant PTGS2 rs20417 CC genotype had a 30% higher Type 2 diabetes prevalence compared with subjects with the GG genotype