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RNASEL

From SNPedia

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EntrezGene6041
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23andMeRNASEL
# SNPs10
 Max MagnitudeChromosome positionSummary
rs145415894182,585,980
rs151296858182,586,632
rs35896902182,581,355
rs37385793182,586,901
rs4869072182,585,422
rs533259182,579,884
rs627839182,572,946
rs627928182,582,202
rs743153640182,586,014
rs743153650182,586,804


The ribonuclease L (RNase L; RNASEL) gene encodes a key enzyme in the interferon induced antiviral and anti-proliferate pathway, in particular through the mobilization of type I interferons, and is thereby involved in cellular viral defense, single-stranded RNA cleavage and tumor suppressor activities such as stress mediated apoptosis, cell proliferation and regulation of protein synthesis.

RNASEL SNPs associated with cancer risk include:

  • rs486907, known as R462Q
  • rs3738579, a SNP in the 5' UTR potentially associated with multiple cancers
  • A SNP lacking an rs# in dbSNP, known as E265X, associated with an 11 year earlier onset of prostate cancer in predisposed families