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rs10008492

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) normal
(C;T) Very small 1.1x increased risk for Non-hodgkin's lymphoma
(T;T) 1.4x increased risk for Non-hodgkin's lymphoma
ReferenceGRCh38 38.1/141
Chromosome4
Position38764099
is asnp
is mentioned by
dbSNPrs10008492
ebirs10008492
HLIrs10008492
Exacrs10008492
Varsomers10008492
Maprs10008492
PheGenIrs10008492
hapmaprs10008492
1000 genomesrs10008492
hgdprs10008492
ensemblrs10008492
gopubmedrs10008492
geneviewrs10008492
scholarrs10008492
googlers10008492
pharmgkbrs10008492
gwascentralrs10008492
openSNPrs10008492
23andMers10008492
23andMe allrs10008492
SNP Nexus

SNPshotrs10008492
SNPdbers10008492
MSV3drs10008492
GWAS Ctlgrs10008492
GMAF0.2576
Max Magnitude
? (C;C) (C;T) (T;T) 28
rs10008492 is a SNP located in a cluster of toll-like receptor genes.

In a pooled analysis including three population-based case-control studies of Non-Hodgkin's lymphoma (1,946 cases, 1,808 controls), two SNPs in moderate linkage disequilibrium were significantly associated with NHL: rs10008492 (odds ratio for (C;T) genotype 1.12, CI: 0.97-1.30; OR(T;T) 1.40, CI: 1.15-1.71; p(trend)=0.001) and rs4833103 (OR(A;C) 0.75, CI: 0.64-0.88; OR(A;A) 0.74, CI: 0.62-0.90; p(trend)=0.002; p(dominant)=0.0002).[PMID 19029192OA-icon.png]

[PMID 19503599OA-icon.png] The impact of divergence time on the nature of population structure: an example from Iceland.

[PMID 20200442OA-icon.png] Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies.

[PMID 21872627] Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk.