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rs10046

From SNPedia

Orientationminus
Stabilizedminus
Make rs10046(C;C)
Make rs10046(C;T)
Make rs10046(T;T)
ReferenceGRCh38 38.1/141
Chromosome15
Position51210789
GeneCYP19A1
is asnp
is mentioned by
dbSNPrs10046
ebirs10046
HLIrs10046
Exacrs10046
Varsomers10046
Maprs10046
PheGenIrs10046
hapmaprs10046
1000 genomesrs10046
hgdprs10046
ensemblrs10046
gopubmedrs10046
geneviewrs10046
scholarrs10046
googlers10046
pharmgkbrs10046
gwascentralrs10046
openSNPrs10046
23andMers10046
23andMe allrs10046
SNP Nexus

SNPshotrs10046
SNPdbers10046
MSV3drs10046
GWAS Ctlgrs10046
GMAF0.41
Max Magnitude
? (C;C) (C;T) (T;T) 28
[PMID 18274619OA-icon.png] rs10046 is a SNP potentially linked in a gender-specific manner to hypertension

[PMID 19152063] rs10046(C;C) associated with miscarriages (P = 0.017)


[PMID 19366906] BRCA1 Breast Cancer Risk Is Modified by CYP19 Polymorphisms in Ashkenazi Jews


[PMID 19573564] Effect of the cytochrome P450 19 (aromatase) gene polymorphism on personality traits in healthy subjects


[PMID 19921206OA-icon.png] Association of polymorphisms in CYP19A1 and CYP3A4 genes with lower urinary tract symptoms, prostate volume, uroflow and PSA in a population-based sample


[PMID 20144226OA-icon.png] A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole


[PMID 19952760] Polymorphisms in estrogen related genes may modify the protective effect of isoflavones against prostate cancer risk in Japanese men

[PMID 20432167] Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians

[PMID 20586553] Polymorphisms in ESR1, ESR2 and HSD17B1 genes are associated with fertility status in endometriosis

[PMID 20797716] Epistasis between CYP19A1 and ESR1 polymorphisms is associated with premature ovarian failure


[PMID 21790896] Genetic and environmental predictors, endogenous hormones and growth factors and risk of estrogen receptor-positive breast cancer in Japanese women


[PMID 22511967OA-icon.png] Potential Role of Aromatase over Estrogen Receptor Gene Polymorphisms in Migraine Susceptibility: A Case Control Study from North India

[PMID 15199113] Polymorphisms associated with circulating sex hormone levels in postmenopausal women.

[PMID 16412218OA-icon.png] Multilocus analysis of SNP and metabolic data within a given pathway.

[PMID 17615053OA-icon.png] Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk.

[PMID 17893373] Sex and body mass index specific regulation of blood pressure by CYP19A1 gene variants.

[PMID 17903296OA-icon.png] Genome-wide association with bone mass and geometry in the Framingham Heart Study.

[PMID 18049890] Single nucleotide polymorphisms of the aromatase gene (CYP19A1), HER2/neu status, and prognosis in breast cancer patients.

[PMID 18086758OA-icon.png] Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set.

[PMID 18159088] Association of FSH receptor and CYP19A1 gene variations with sterility and ovarian hyperstimulation syndrome.

[PMID 18199708OA-icon.png] Haplotype analyses of CYP19A1 gene variants and breast cancer risk: results from the Shanghai Breast Cancer Study.

[PMID 18245543] A single-nucleotide polymorphism in the aromatase gene is associated with the efficacy of the aromatase inhibitor letrozole in advanced breast carcinoma.

[PMID 18603647OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

[PMID 18622258OA-icon.png] Association of genetic polymorphisms in CYP19A1 and blood levels of sex hormones among postmenopausal Chinese women.

[PMID 18628428OA-icon.png] Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.

[PMID 18629629] Association of genetic polymorphisms of ER-alpha and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women.

[PMID 18636124OA-icon.png] Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.

[PMID 18941913OA-icon.png] Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancer.

[PMID 19015200OA-icon.png] Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer.

[PMID 19064562OA-icon.png] Genetic variation in CYP19A1 and risk of breast cancer and fibrocystic breast conditions among women in Shanghai, China.

[PMID 19630952OA-icon.png] Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women.

[PMID 19794821OA-icon.png] Anastrozole Use in Early Stage Breast Cancer of Post-Menopausal Women.

[PMID 21269619] Epistasis between FSHR and CYP19A1 polymorphisms is associated with premature ovarian failure.


[PMID 23342035OA-icon.png] Associations between Aromatase CYP19 rs10046 Polymorphism and Breast Cancer Risk: From a Case-Control to a Meta-Analysis of 20,098 Subjects


[PMID 23129173OA-icon.png] Plasma estrone sulfate concentrations and genetic variation at the CYP19A1 locus in postmenopausal women with early breast cancer treated with letrozole


[PMID 23700878] Research on aromatase gene (CYP19A1) polymorphisms as a predictor of endocrine therapy effectiveness in breast cancer


[PMID 24402127OA-icon.png] Analysis of the rs10046 Polymorphism of Aromatase (CYP19) in Premenopausal Onset of Human Breast Cancer


[PMID 22633539OA-icon.png] Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer.


[PMID 23669293] CYP19A1 gene polymorphisms and risk of lung cancer.


[PMID 23809139] Polymorphic variants of CYP17 and CYP19A and risk of infertility in endometriosis.


[PMID 24968701OA-icon.png] CYP19 gene variant confers susceptibility to endometriosis-associated infertility in Chinese women


[PMID 24274352] Green tea consumption and breast cancer risk in Japanese women: a case-control study


[PMID 25109722OA-icon.png] Role of genetic & environment risk factors in the aetiology of colorectal cancer in Malaysia


[PMID 26415088] Sex and Obesity-specific Association of Aromatase (CYP19A1) Gene Variant with Apolipoprotein B and Hypertension


[PMID 26463708] Association of Variants in Candidate Genes with Lipid Profiles in Women with Early Breast Cancer on Adjuvant Aromatase Inhibitor Therapy


[PMID 27825388] Impact of CYP19A1 and ESR1 variants on early-onset side effects during combined endocrine therapy in the TEXT trial.