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rs10069690

From SNPedia

Orientationplus
Stabilizedplus
Make rs10069690(C;C)
Make rs10069690(C;T)
Make rs10069690(T;T)
ReferenceGRCh38 38.1/141
Chromosome5
Position1279675
GeneTERT
is asnp
is mentioned by
dbSNPrs10069690
ebirs10069690
HLIrs10069690
Exacrs10069690
Varsomers10069690
Maprs10069690
PheGenIrs10069690
hapmaprs10069690
1000 genomesrs10069690
hgdprs10069690
ensemblrs10069690
gopubmedrs10069690
geneviewrs10069690
scholarrs10069690
googlers10069690
pharmgkbrs10069690
gwascentralrs10069690
openSNPrs10069690
23andMers10069690
23andMe allrs10069690
SNP Nexus

SNPshotrs10069690
SNPdbers10069690
MSV3drs10069690
GWAS Ctlgrs10069690
GMAF0.3182
Max Magnitude
? (C;C) (C;T) (T;T) 28
GWAS snp
PMID [PMID 22037553OA-icon.png]
Trait
Title A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer.
Risk Allele T
P-val 1E-10
Odds Ratio 1.1800 None


[PMID 21269955] [hTERT single nucleotide polymorphism is associated with increased risks of hepatocellular carcinoma and tumor metastasis].


[PMID 22267287OA-icon.png] Telomere length and genetic variation in telomere maintenance genes in relation to ovarian cancer risk.


[PMID 23136140OA-icon.png] Genetic susceptibility loci for subtypes of breast cancer in an African American population


[PMID 23535731OA-icon.png] Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

GWAS snp
PMID [PMID 23535733OA-icon.png]
Trait Breast cancer
Title Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
Risk Allele T
P-val 5E-12
Odds Ratio 1.15 [1.11-1.20]
GWAS snp
PMID [PMID 23535729OA-icon.png]
Trait Breast cancer
Title Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Risk Allele T
P-val 7E-9
Odds Ratio 1.06 [1.04-1.09]


[PMID 24292274] A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia


[PMID 23001564OA-icon.png] Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans.


[PMID 23535824OA-icon.png] Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression.


[PMID 23629941OA-icon.png] Telomere length, telomere-related genes, and breast cancer risk: the breast cancer health disparities study.


[PMID 25027329] Imputation and subset based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

GWAS snp
PMID [PMID 24325915OA-icon.png]
Trait Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative)
Title Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer.
Risk Allele A
P-val 1E-7
Odds Ratio 1.24 [1.14-1.34]


[PMID 25738283] Association of genetic polymorphisms in the telomerase reverse transcriptase gene with prostate cancer aggressiveness


[PMID 26053551OA-icon.png] A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase


[PMID 25254308] Polymorphisms in the TERT gene are associated with lung cancer risk in the Chinese Han population


[PMID 26143636] TERT promoter mutations and polymorphisms as prognostic factors in primary glioblastoma


[PMID 26294352] Association of human telomerase reverse transcriptase gene polymorphisms, serum levels, and telomere length with renal cell carcinoma risk and pathology


[PMID 26320593] A single-nucleotide polymorphism of CCL21 rs951005 T>C is associated with susceptibility of polymyositis and such patients with interstitial lung disease in a Chinese Han population.


[PMID 27594435] Genome-wide Association Studies in Women of African Ancestry Identified 3q26.21 as a Novel Susceptibility Locus for Estrogen Receptor Negative Breast Cancer.


[PMID 27825130] Genetic variants in TERT are associated with risk of gastric cancer in a Chinese Han population.