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rs10088218

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2 0.5x decreased risk for ovarian cancer
(A;G) 1.25 0.76x decreased risk for ovarian cancer
(G;G) 0
ReferenceGRCh38 38.1/142
Chromosome8
Position128531703
GeneLINC00824
is asnp
is mentioned by
dbSNPrs10088218
ebirs10088218
HLIrs10088218
Exacrs10088218
Varsomers10088218
Maprs10088218
PheGenIrs10088218
hapmaprs10088218
1000 genomesrs10088218
hgdprs10088218
ensemblrs10088218
gopubmedrs10088218
geneviewrs10088218
scholarrs10088218
googlers10088218
pharmgkbrs10088218
gwascentralrs10088218
openSNPrs10088218
23andMers10088218
23andMe allrs10088218
SNP Nexus

SNPshotrs10088218
SNPdbers10088218
MSV3drs10088218
GWAS Ctlgrs10088218
GMAF0.08448
Max Magnitude2
rs10088218 is a SNP on chromosome 8q24, >700 kb distal to the CMYC gene in an area termed a 'gene desert'.

A genome-wide association study ultimately including over 10,000 ovarian cancer patients found statistically strong (p = 8 × 10e-15) evidence for slightly reduced risk associated with the rs10088218(A) allele, with an odds ratio of 0.76 (CI: 0.7 – 0.81) as calculated for the serous subtype (of ovarian cancer).[PMID 20852632OA-icon.png]

A large study of over 18,000 patients with epithelial ovarian cancer, including BRCA1 and BRCA2 carriers and a meta-analysis, has also found similar levels of decreased risk for the rs10088218(A) allele.[PMID 25581431OA-icon.png]
? (A;A) (A;G) (G;G) 28
GWAS snp
PMID [PMID 20852632OA-icon.png]
Trait
Title A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24
Risk Allele G
P-val 3E-9
Odds Ratio 1.19 [1.12-1.25]


[PMID 22235027OA-icon.png] Evaluation of microRNA expression profiles and their associations with risk alleles in lymphoblastoid cell lines of familial ovarian cancer.


[PMID 22253144OA-icon.png] Ovarian cancer susceptibility alleles and risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers.

GWAS snp
PMID [PMID 23535730OA-icon.png]
Trait Ovarian cancer
Title GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
Risk Allele
P-val 1E-17
Odds Ratio 1.29 [1.21-1.36]


[PMID 23133607OA-icon.png] Associations between gene expression variations and ovarian cancer risk alleles identified from genome wide association studies.


[PMID 25173882OA-icon.png] Replication Study for the Association of Seven Genome- Gwas-Identified Loci With Susceptibility to Ovarian Cancer in the Polish Population