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rs10090154

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 normal
(C;T) 2 1.4x increased risk for prostate cancer
(T;T) 2.1 1.4x increased risk for prostate cancer
ReferenceGRCh38 38.1/141
Chromosome8
Position127519892
is asnp
is mentioned by
dbSNPrs10090154
ebirs10090154
HLIrs10090154
Exacrs10090154
Varsomers10090154
Maprs10090154
PheGenIrs10090154
hapmaprs10090154
1000 genomesrs10090154
hgdprs10090154
ensemblrs10090154
gopubmedrs10090154
geneviewrs10090154
scholarrs10090154
googlers10090154
pharmgkbrs10090154
gwascentralrs10090154
openSNPrs10090154
23andMers10090154
23andMe allrs10090154
SNP Nexus

SNPshotrs10090154
SNPdbers10090154
MSV3drs10090154
GWAS Ctlgrs10090154
GMAF0.1295
Max Magnitude2.1
? (C;C) (C;T) (T;T) 28
rs10090154 is a SNP in chromosome 8q24 "region 1", associated with increased risk for prostate cancer. The odds ratio for the (T) risk allele were 1.42 (CI: 1.07-1.87, p=0.014), and they were not significantly different between Caucasians and African-Americans in this study of ~500 patients.[PMID 18231127OA-icon.png]

In follow-up studies looking at disease severity (and not just overall risk), this SNP is reported to account for the risk (from region 1) of advanced prostate cancer.[PMID 18231127OA-icon.png]

Note that a meta-analysis across 10+ studies, including over 15,000 prostate cancer cases, reported the risk for a different SNP (rs1447295) representing the same region, "region 1", of this chromosome.[PMID 1823127]


[PMID 19857256OA-icon.png] Association between an 8q24 locus and the risk of colorectal cancer in Japanese


[PMID 19866473OA-icon.png] Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men


[PMID 21051319OA-icon.png] Risk of Urinary Bladder Cancer is Associated with 8q24 Variant rs9642880[T]: Results from the Los Angeles-Shanghai Case-Control Study

OMIM611100
Desc
Variant
Relatedalso
[PMID 22549899OA-icon.png] Genetic polymorphism and prostate cancer aggressiveness: A case-only study of 1,536 GWAS and candidate SNPs in African-Americans and European-Americans


[PMID 17618282OA-icon.png] A common genetic risk factor for colorectal and prostate cancer.


[PMID 18349290] Association of genetic variants at 8q24 with breast cancer risk.


[PMID 18360876OA-icon.png] Chromosome 8q24 markers: risk of early-onset and familial prostate cancer.


[PMID 18483343] Multiple independent genetic variants in the 8q24 region are associated with prostate cancer risk.


[PMID 18577746OA-icon.png] Multiple loci with different cancer specificities within the 8q24 gene desert.


[PMID 18704501OA-icon.png] Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers.


[PMID 19155440OA-icon.png] Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21.


[PMID 19520795OA-icon.png] Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans.


[PMID 19680443OA-icon.png] Functional enhancers at the gene-poor 8q24 cancer-linked locus.


[PMID 20039378OA-icon.png] Estimation of genotype relative risks from pedigree data by retrospective likelihoods.


[PMID 20584312OA-icon.png] 8q24 sequence variants in relation to prostate cancer risk among men of African descent: a case-control study.


[PMID 20690139] Meta-analysis of genome-wide and replication association studies on prostate cancer.


[PMID 22099997] Risk loci on chromosome 8q24 are associated with prostate cancer in northern Chinese men.

GWAS snp
PMID [PMID 22923026OA-icon.png]
Trait Prostate cancer
Title Evaluating genetic risk for prostate cancer among Japanese and Latinos.
Risk Allele T
P-val 3E-6
Odds Ratio 1.68 [1.35-2.09]


[PMID 23935004OA-icon.png] Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia


[PMID 23628314] A replication study examining association of rs6983267, rs10090154, and rs1447295 common single nucleotide polymorphisms in 8q24 region with prostate cancer in Siberians.