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rs10166942

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 1.3 0.7x lower risk for migraines
(C;T) 1.1 0.85x lower risk for migraines
(T;T) 0 common in complete genomics
ReferenceGRCh38 38.1/141
Chromosome2
Position233916448
GeneTRPM8
is asnp
is mentioned by
dbSNPrs10166942
ebirs10166942
HLIrs10166942
Exacrs10166942
Varsomers10166942
Maprs10166942
PheGenIrs10166942
hapmaprs10166942
1000 genomesrs10166942
hgdprs10166942
ensemblrs10166942
gopubmedrs10166942
geneviewrs10166942
scholarrs10166942
googlers10166942
pharmgkbrs10166942
gwascentralrs10166942
openSNPrs10166942
23andMers10166942
23andMe allrs10166942
SNP Nexus

SNPshotrs10166942
SNPdbers10166942
MSV3drs10166942
GWAS Ctlgrs10166942
GMAF0.4715
Max Magnitude1.3
? (C;C) (C;T) (T;T) 28
rs10166942 is a SNP on ch 2q37.1 in the TRPM8 gene.

A large GWAS study of over 5,000 patients with migraines and a meta-analysis concluded that this SNP was one of three influencing the condition, albeit with only slight risk changes on its own. The odds ratio for the less common rs10166942(C) allele was 0.85 (CI: 0.82 - 0.89, p = 5.5 x 10e-12).10.1038/ng.856

GWAS snp
PMID [PMID 21666692OA-icon.png]
Trait
Title Genome-wide association study reveals three susceptibility loci for common migraine in the general population.
Risk Allele T
P-val 6E-12
Odds Ratio 1.1800 [1.12-1.22]


[PMID 22072275OA-icon.png] Genetics of migraine in the age of genome-wide association studies

GWAS snp
PMID [PMID 22683712OA-icon.png]
Trait
Title Genome-wide association analysis identifies susceptibility loci for migraine without aura.
Risk Allele
P-val 1E-12
Odds Ratio 1.2800 None


[PMID 24021092] PRDM16 rs2651899 Variant Is a Risk Factor for Chinese Common Migraine Patients


[PMID 23294458] Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine


[PMID 24674449OA-icon.png] A replication study of GWAS findings in migraine identifies association in a Swedish case-control sample