Have questions? Visit https://www.reddit.com/r/SNPedia

rs1018381

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0.1 normal cognitive ability
(T;T) 2 impaired cognitive ability
Make rs1018381(C;T)
ReferenceGRCh38 38.1/141
Chromosome6
Position15656839
GeneDTNBP1
is asnp
is mentioned by
dbSNPrs1018381
ebirs1018381
HLIrs1018381
Exacrs1018381
Varsomers1018381
Maprs1018381
PheGenIrs1018381
hapmaprs1018381
1000 genomesrs1018381
hgdprs1018381
ensemblrs1018381
gopubmedrs1018381
geneviewrs1018381
scholarrs1018381
googlers1018381
pharmgkbrs1018381
gwascentralrs1018381
openSNPrs1018381
23andMers1018381
23andMe allrs1018381
SNP Nexus

SNPshotrs1018381
SNPdbers1018381
MSV3drs1018381
GWAS Ctlgrs1018381
GMAF0.1423
Max Magnitude2
? (C;C) (C;T) (T;T) 28

g2b2mh blog In a population of healthy individuals, those that carry common variants (such as rs760761, rs1018381, rs2619522) located in the dysbindin (DTNBP1) gene, a risk factor for schizophrenia, show minor cognitive impairments such as decreased attentional capacity, worse performance on memory tasks, and alterations in schizotypal beliefs and experiences.


[PMID 19335929] Association of the DTNBP1 genotype with cognition and personality traits in healthy subjects.


[PMID 19497374] Genetic variation in schizophrenia-risk-gene dysbindin 1 modulates brain activation in anterior cingulate cortex and right temporal gyrus during language production in healthy individuals


[PMID 19077176] Variation in the dysbindin gene and normal cognitive function in three independent population samples

OMIM607145
DescDYSTROBREVIN-BINDING PROTEIN 1; DTNBP1
Variant
Relatedalso

[PMID 19621369] The impact of dystrobrevin-binding protein 1 (DTNBP1) on neural correlates of episodic memory encoding and retrieval

[PMID 19650139] Impact of schizophrenia-risk gene dysbindin 1 on brain activation in bilateral middle frontal gyrus during a working memory task in healthy individuals


[PMID 20846375OA-icon.png] The effects of a DTNBP1 gene variant on attention networks: an fMRI study

[PMID 21130223OA-icon.png] Meta-Analysis of Genetic Variation in DTNBP1 and General Cognitive Ability


[PMID 12098102OA-icon.png] Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia.


[PMID 12474144OA-icon.png] Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families.


[PMID 14618545OA-icon.png] The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease.


[PMID 15290652OA-icon.png] A powerful strategy to account for multiple testing in the context of haplotype analysis.


[PMID 15362017OA-icon.png] Association of the DTNBP1 locus with schizophrenia in a U.S. population.


[PMID 17033966OA-icon.png] Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.


[PMID 17074466OA-icon.png] DTNBP1 genotype influences cognitive decline in schizophrenia.


[PMID 17445278OA-icon.png] Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings.


[PMID 18663367OA-icon.png] The dystrobrevin-binding protein 1 gene: features and networks.


[PMID 18715757OA-icon.png] Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.


[PMID 18797396] Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression.


[PMID 18804346OA-icon.png] Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia.


[PMID 19369910OA-icon.png] The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation.


[PMID 19862852OA-icon.png] Association study of DTNBP1 with schizophrenia in a US sample.


[PMID 19911060OA-icon.png] Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.


[PMID 22019876] The impact of a Dysbindin schizophrenia susceptibility variant on fiber tract integrity in healthy individuals: a TBSS-based diffusion tensor imaging study.


[PMID 22580710OA-icon.png] The DTNBP1 (dysbindin-1) gene variant rs2619522 is associated with variation of hippocampal and prefrontal grey matter volumes in humans.


[PMID 22911901] Association of genetic variations in DTNBP1 with cognitive function in schizophrenia patients and healthy subjects.