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rs10192566

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) if diabetic, poorer response to rosiglitazone
(C;G) if diabetic, better response to rosiglitazone
(G;G) if diabetic, better response to rosiglitazone
ReferenceGRCh38 38.1/141
Chromosome2
Position11750302
GeneLPIN1
is asnp
is mentioned by
dbSNPrs10192566
ebirs10192566
HLIrs10192566
Exacrs10192566
Varsomers10192566
Maprs10192566
PheGenIrs10192566
hapmaprs10192566
1000 genomesrs10192566
hgdprs10192566
ensemblrs10192566
gopubmedrs10192566
geneviewrs10192566
scholarrs10192566
googlers10192566
pharmgkbrs10192566
gwascentralrs10192566
openSNPrs10192566
23andMers10192566
23andMe allrs10192566
SNP Nexus

SNPshotrs10192566
SNPdbers10192566
MSV3drs10192566
GWAS Ctlgrs10192566
GMAF0.4734
Max Magnitude
A total of 262 Korean type-2 diabetes patients were treated with 12 weeks of rosiglitazone at 4mg/day and genotyped to reveal that rs10192566(G) allele carriers responded better than (C) carriers. Patients with rs10192566(G) alleles had a larger decrease in fasting plasma glucose, 2-h postprandial glucose, and HbA1c than rs10192566(C;C) homozygotes. None of the other LPIN1 gene SNPs tested were associated with response.[PMID 18693052]

Note: rs11693809, rs10192566, and rs2278513 are in nearly complete linkage disequilibrium (D'>0.958, r(2) >0.882).



GET Evidence
rs10192566
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.578125
summary