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rs10210302

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 normal
(C;T) 1.2x risk
(T;T) 1.8x risk
ReferenceGRCh38 38.1/141
Chromosome2
Position233250193
GeneATG16L1
is asnp
is mentioned by
dbSNPrs10210302
ebirs10210302
HLIrs10210302
Exacrs10210302
Varsomers10210302
Maprs10210302
PheGenIrs10210302
hapmaprs10210302
1000 genomesrs10210302
hgdprs10210302
ensemblrs10210302
gopubmedrs10210302
geneviewrs10210302
scholarrs10210302
googlers10210302
pharmgkbrs10210302
gwascentralrs10210302
openSNPrs10210302
23andMers10210302
23andMe allrs10210302
SNP Nexus

SNPshotrs10210302
SNPdbers10210302
MSV3drs10210302
GWAS Ctlgrs10210302
GMAF0.3903
Max Magnitude0
? (C;C) (C;T) (T;T) 28
rs10210302 has been reported in a large study to be associated with Crohn's disease.

The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.19 (CI 1.01-1.41), and for homozygotes, 1.85 (CI 1.56-2.21). [PMID 17554300OA-icon.png]

OMIM611081
DescINFLAMMATORY BOWEL DISEASE 10; IBD10
Variant
Relatedalso
[PMID 18224312OA-icon.png] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.


[PMID 18438406OA-icon.png] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.


[PMID 18533027OA-icon.png] Worldwide population differentiation at disease-associated SNPs.


[PMID 20846217OA-icon.png] Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.


GET Evidence
rs10210302
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.367188
summary



[PMID 25712183] Genetic polymorphism in ATG16L1 gene influences the response to adalimumab in Crohn's disease patients