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rs10260404

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 2 1.60x risk of developing ALS
(C;T) 1.5 1.20x risk of developing ALS
(T;T) 1 Normal risk of developing ALS
ReferenceGRCh38 38.1/141
Chromosome7
Position154513713
GeneDPP6
is asnp
is mentioned by
dbSNPrs10260404
ebirs10260404
HLIrs10260404
Exacrs10260404
Varsomers10260404
Maprs10260404
PheGenIrs10260404
hapmaprs10260404
1000 genomesrs10260404
hgdprs10260404
ensemblrs10260404
gopubmedrs10260404
geneviewrs10260404
scholarrs10260404
googlers10260404
pharmgkbrs10260404
gwascentralrs10260404
openSNPrs10260404
23andMers10260404
23andMe allrs10260404
SNP Nexus

SNPshotrs10260404
SNPdbers10260404
MSV3drs10260404
GWAS Ctlgrs10260404
GMAF0.2888
Max Magnitude2
? (C;C) (C;T) (T;T) 28
rs10260404, a SNP in the region of the DPP6 gene on chromosome 7, has been associated with the sporadic form of ALS (Lou Gehrig's disease) in a study of 1000+ European patients. The overall odds ratio for the risk allele rs10260404(C) is 1.30 (CI: 1.18-1.43, p=0.017). When broken down by genotype, the odds ratios for heterozygotes are 1.20 (CI: 1.06-1.41), and for rs10260404(C;C) homozygotes, 1.60 (CI: 1.32-1.92).[PMID 18084291]

A "C-C" haplotype for this SNP and that of it's neighbor rs10239794 is also highly (statistically; p=10e-9) associated with ALS. [PMID 18084291]

However, in an expanded study pooling 4 populations (Irish, Dutch, US, Polish) rs10260404 failed to reach Bonferroni significance. although it did remain significant in the (expanded) Irish-only population.[PMID 18987618OA-icon.png]

GWAS
SNP rs10260404
PubMedID [PMID 18057069]
Condition Amyotrophic lateral sclerosis
Gene DPP6
Risk Allele
pValue 3.00E-006
OR 1.37
95% CI 1.20-1.56






[PMID 19193627OA-icon.png] A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.


[PMID 19525032] No association of DPP6 with amyotrophic lateral sclerosis in an Italian population.


[PMID 20137488] Association between DPP6 polymorphism and the risk of sporadic amyotrophic lateral sclerosis in Chinese patients.


GET Evidence
rs10260404
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.273438
summary



[PMID 22795786] No association of five candidate genetic variants with amyotrophic lateral sclerosis in a Chinese population