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rs10306114

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal
(A;G) 2 Higher risk of bleeding during coronary angiography
(G;G) 3 Higher risk of bleeding during coronary angiography
ReferenceGRCh38 38.1/141
Chromosome9
Position122370243
GenePTGS1
is asnp
is mentioned by
dbSNPrs10306114
ebirs10306114
HLIrs10306114
Exacrs10306114
Varsomers10306114
Maprs10306114
PheGenIrs10306114
hapmaprs10306114
1000 genomesrs10306114
hgdprs10306114
ensemblrs10306114
gopubmedrs10306114
geneviewrs10306114
scholarrs10306114
googlers10306114
pharmgkbrs10306114
gwascentralrs10306114
openSNPrs10306114
23andMers10306114
23andMe allrs10306114
SNP Nexus

SNPshotrs10306114
SNPdbers10306114
MSV3drs10306114
GWAS Ctlgrs10306114
GMAF0.05923
Max Magnitude3
rs10306114, also known as -842A>G, is a SNP upstream of the cyclooxygenase-1 PTGS1 gene.

A study of 696 European patients undergoing elective diagnostic coronary angiographies (CAGs) because of suspected or proven stable coronary artery disease found that 23 experienced bleeding, perhaps the most common complication of this type of invasive coronary procedure. After controlling for various variables (especially gender), two co-inherited SNPs, rs10306114 and rs3842787, were found to be associated with higher risk for bleeding in otherwise low risk patients who (i) did undergo percutaneous coronary intervention and (ii) did not take clopidogrel. Having the less common haplotype (rs10306114(G) and/or rs3842787(T)) increases the bleeding risk upon CAG ~12 fold (p = 0.012).[PMID 20691446]


[PMID 19786296] Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction


[PMID 17301694OA-icon.png] Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1).


[PMID 17495879OA-icon.png] Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study.


[PMID 19046748OA-icon.png] Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.


ClinVar
Risk rs10306114(G;G)
Alt rs10306114(G;G)
Reference rs10306114(A;A)
Significance Drug-response
Disease aspirin response - Efficacy
Variation info
Gene PTGS1
CLNDBN aspirin response - Efficacy
Reversed 0
HGVS NC_000009.11:g.125132522A>G
CLNSRC PharmGKB Clinical Annotation PharmGKB
CLNACC RCV000211226.1,