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rs1031681

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 1.3 1.3x increased risk for depression (for those under 55)
(A;G) 0
(G;G) 0 normal
ReferenceGRCh38 38.1/141
Chromosome12
Position84526555
is asnp
is mentioned by
dbSNPrs1031681
ebirs1031681
HLIrs1031681
Exacrs1031681
Varsomers1031681
Maprs1031681
PheGenIrs1031681
hapmaprs1031681
1000 genomesrs1031681
hgdprs1031681
ensemblrs1031681
gopubmedrs1031681
geneviewrs1031681
scholarrs1031681
googlers1031681
pharmgkbrs1031681
gwascentralrs1031681
openSNPrs1031681
23andMers1031681
23andMe allrs1031681
SNP Nexus

SNPshotrs1031681
SNPdbers1031681
MSV3drs1031681
GWAS Ctlgrs1031681
GMAF0.4284
Max Magnitude1.3
? (A;A) (A;G) (G;G) 28
rs1031681 is one of two linked SNPs potentially associated (at a distance though) with the SLC6A15 gene; the other is rs1545843.

A GWAS study and meta-analysis ultimately including six independent samples, primarily Caucasion/European but also including an African-American sample, found that the rs1031681(A) allele was associated with higher risk for major depression, but only in individuals less than 55 years old and only when homozygous, with an odds ratio of 1.3 (p = 5 x 10e-5).[PMID 21521612OA-icon.png]