- 375 case and 812 control subjects
- rs10399805 p = .018 and rs2275351; p = .008.
[PMID 18767121] An attempt to repeat the association between rs10399805 and risk for schizophrenia in an ethnically identical population (Japanese) as well as a new population (Han Chinese) failed to show any significant association.
[PMID 19106306] rs10399805(T;T) genotype showed a 2.5-fold increase in CHI3L1 mRNA expression in peripheral blood cells than those with (C;C) which is associated with the risk of atopy.
[PMID 20051317] The chitinase 3-like 1 gene and schizophrenia: Evidence from a multi-center case-control study and meta-analysis
[PMID 17160890] Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia.
[PMID 18403759] Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function.
[PMID 19568425] Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults.
[PMID 21257319] Genetic polymorphisms in chitinase 3-like 1 (CHI3L1) are associated with circulating YKL-40 levels, but not with angiographic coronary artery disease in a Chinese population.
|qualified_impact||Insufficiently evaluated pharmacogenetic|
[PMID 25203433] Correlation of Chitinase 3-Like 1 Single Nucleotide Polymorphisms and Haplotypes with Uterine Cervical Cancer in Taiwanese Women