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rs10411210

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0
(T;T) 2.1 1.15x increased risk of colorectal cancer
Make rs10411210(C;T)
ReferenceGRCh38 38.1/141
Chromosome19
Position33041394
GeneRHPN2
is asnp
is mentioned by
dbSNPrs10411210
ebirs10411210
HLIrs10411210
Exacrs10411210
Varsomers10411210
Maprs10411210
PheGenIrs10411210
hapmaprs10411210
1000 genomesrs10411210
hgdprs10411210
ensemblrs10411210
gopubmedrs10411210
geneviewrs10411210
scholarrs10411210
googlers10411210
pharmgkbrs10411210
gwascentralrs10411210
openSNPrs10411210
23andMers10411210
23andMe allrs10411210
SNP Nexus

SNPshotrs10411210
SNPdbers10411210
MSV3drs10411210
GWAS Ctlgrs10411210
GMAF0.213
Max Magnitude2.1
? (C;C) (C;T) (T;T) 28

nature colorectal cancer rs10411210 RHPN2; P = 4.6 times 10-9)

In a replication study of ~1,800 Swedish patients, the rs10411210(T) allele was specifically also shown to be associated with younger age of onset for colorectal cancer.[PMID 20648012OA-icon.png]

GWAS snp
PMID [PMID 19011631OA-icon.png]
Trait Colorectal cancer
Title Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
Risk Allele C
P-val 5E-9
Odds Ratio 1.15 [1.10-1.20]
OMIM612591
DescCOLORECTAL CANCER, SUSCEPTIBILITY TO, 10; CRCS10
Variant
Relatedalso
[PMID 21119214OA-icon.png] Colorectal Cancer Susceptibility Loci in a Population-Based Study: Associations with Morphological Parameters


[PMID 22363440OA-icon.png] cis-Expression QTL Analysis of Established Colorectal Cancer Risk Variants in Colon Tumors and Adjacent Normal Tissue


[PMID 22367214OA-icon.png] Characterization of gene-environment interactions for colorectal cancer susceptibility loci

[PMID 19639606OA-icon.png] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.

[PMID 20501757OA-icon.png] Low-penetrance susceptibility variants in familial colorectal cancer.

[PMID 21071539OA-icon.png] Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.

[PMID 21314996OA-icon.png] Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.

[PMID 22045029] Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.

[PMID 22235025] Susceptibility genetic variants associated with early-onset colorectal cancer.


GET Evidence
rs10411210
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.203125
summary



[PMID 23359760OA-icon.png] Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population


[PMID 22848671OA-icon.png] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.


[PMID 22999960OA-icon.png] Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas.


[PMID 23434150OA-icon.png] Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?


[PMID 24854447] Association analysis of colorectal cancer susceptibility variants with gastric cancer in a Chinese Han population


[PMID 25021488] PWE-010 The Association Of Tgfb Signalling Pathway Gene Polymorphisms With Colorectal Cancer Risk: A Meta-analysis

GWAS snp
PMID [PMID 24836286OA-icon.png]
Trait Colorectal cancer
Title Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
Risk Allele C
P-val 3E-6
Odds Ratio 1.12 [1.07-1.17]