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rs1041981

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2 Higher myocardial infarction risk
(C;C) normal
Make rs1041981(A;C)
ReferenceGRCh38 38.1/141
Chromosome6
Position31573007
GeneHLA-DQA1, LTA
is asnp
is mentioned by
dbSNPrs1041981
ebirs1041981
HLIrs1041981
Exacrs1041981
Varsomers1041981
Maprs1041981
PheGenIrs1041981
hapmaprs1041981
1000 genomesrs1041981
hgdprs1041981
ensemblrs1041981
gopubmedrs1041981
geneviewrs1041981
scholarrs1041981
googlers1041981
pharmgkbrs1041981
gwascentralrs1041981
openSNPrs1041981
23andMers1041981
23andMe allrs1041981
SNP Nexus

SNPshotrs1041981
SNPdbers1041981
MSV3drs1041981
GWAS Ctlgrs1041981
GMAF0.3994
Max Magnitude2
? (A;A) (A;C) (C;C) 28
[PMID 18700950OA-icon.png] 827 males and 709 females, 606 subjects without cancer and 930 subjects with various cancers
  • rs1041981(A;C) (C804A, T60N) associated with lung cancer (CA + AA: CC, adjusted OR = 0.60, 95% CI = 0.37 - 0.97),

in males but not in females

OMIM153440
DescMYOCARDIAL INFARCTION, SUSCEPTIBILITY TO
Variant0001
Relatedalso
Neighborrs1799724
Distance1698
Neighborrs2229094
Distance228
[PMID 19167443OA-icon.png] Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia


[PMID 20177654] Obesity-dependent association of TNF-LTA locus with type 2 diabetes in North Indians


[PMID 20459604OA-icon.png] Large-scale association analysis of TNF/LTA gene region polymorphisms in type 2 diabetes


[PMID 21291465] The association of genetic polymorphisms with cerebral palsy: a meta-analysis


[PMID 21628868] Haplotype-based association of four lymphotoxin-alpha gene polymorphisms with the risk of coronary artery disease in han chinese


[PMID 22419714] Effect of Type 2 Diabetes Predisposing Genetic Variants on Colorectal Cancer Risk


[PMID 22310064] Polymorphisms of LTA, LGALS2, and PSMA6 genes and coronary atherosclerosis: a pathological study of 1503 consecutive autopsy cases


ClinVar
Risk rs1041981(A;A)
Alt rs1041981(A;A)
Reference rs1041981(C;C)
Significance Other
Disease Myocardial infarction
Variation info
Gene LTA
CLNDBN Myocardial infarction
Reversed 0
HGVS NC_000006.11:g.31540784C>A
CLNSRC OMIM Allelic Variant
CLNACC RCV000015455.2,



[PMID 15371359OA-icon.png] Testing for Hardy-Weinberg equilibrium in samples with related individuals.


[PMID 16175505OA-icon.png] Identification of four gene variants associated with myocardial infarction.


[PMID 16839190OA-icon.png] Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study.


[PMID 17517687] Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans.


[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.


[PMID 18398712] No association found between the promoter variants of TNF-alpha and diabetic retinopathy in Chinese patients with type 2 diabetes.


[PMID 18513389OA-icon.png] New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.


[PMID 18575614OA-icon.png] Association between LTA, TNF and AGER polymorphisms and late diabetic complications.


[PMID 18615156OA-icon.png] Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.


[PMID 18704761OA-icon.png] Molecular genetics of myocardial infarction.


[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.


[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.


[PMID 19263529OA-icon.png] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.


[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.


[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.


[PMID 19585495] Association of HLA-DRB1, interleukin-6 and cyclin D1 polymorphisms with cervical cancer in the Swedish population--a candidate gene approach.


[PMID 19629486] Lymphotoxin alfa and receptor-interacting protein kinase 1 gene polymorphisms may correlate with prognosis in patients with diffuse large B cell lymphoma treated with R-CHOP.


[PMID 20668555OA-icon.png] Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunity.


GET Evidence
LTA-T60N
aa_change Thr60Asn
aa_change_short T60N
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.403775
summary



[PMID 23996684OA-icon.png] Cytokine and cytokine receptor genes of the adaptive immune response are differentially associated with breast cancer risk in American women of African and European ancestry


[PMID 24587567OA-icon.png] Cytokine polymorphisms are associated with poor sleep maintenance in adults living with human immunodeficiency virus/acquired immunodeficiency syndrome


[PMID 24896147] Role of TNF block genetic variants in HIV-associated sensory neuropathy in black Southern Africans