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rs10423928

From SNPedia

Orientationplus
Stabilizedplus
Make rs10423928(A;A)
Make rs10423928(A;T)
Make rs10423928(T;T)
ReferenceGRCh38 38.1/141
Chromosome19
Position45679046
GeneGIPR
is asnp
is mentioned by
dbSNPrs10423928
ebirs10423928
HLIrs10423928
Exacrs10423928
Varsomers10423928
Maprs10423928
PheGenIrs10423928
hapmaprs10423928
1000 genomesrs10423928
hgdprs10423928
ensemblrs10423928
gopubmedrs10423928
geneviewrs10423928
scholarrs10423928
googlers10423928
pharmgkbrs10423928
gwascentralrs10423928
openSNPrs10423928
23andMers10423928
23andMe allrs10423928
SNP Nexus

SNPshotrs10423928
SNPdbers10423928
MSV3drs10423928
GWAS Ctlgrs10423928
GMAF0.1928
Max Magnitude
? (A;A) (A;T) (T;T) 28
GWAS snp
PMID [PMID 20081857OA-icon.png]
Trait Two-hour glucose challenge
Title Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
Risk Allele A
P-val 3E-12
Odds Ratio 0.09 [0.07-0.11] mmol/L increase


OMIM137241
Desc
Variant
Relatedalso
OMIM613460
Desc
Variant
Relatedalso


[PMID 21747410] Association between the GIPR gene and the insulin level after glucose loading in schizophrenia patients treated with olanzapine.

[PMID 21810601OA-icon.png] Pleiotropic effects of GIP on islet function involve osteopontin.

[PMID 22399504] Genetic variation in the glucose-dependent insulinotropic polypeptide receptor modifies the association between carbohydrate and fat intake and risk of type 2 diabetes in the Malmo Diet and Cancer cohort.


GET Evidence
rs10423928
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.206349
summary



GWAS snp
PMID [PMID 23563607OA-icon.png]
Trait Obesity
Title Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Risk Allele T
P-val 4E-13
Odds Ratio 1.16 [NR]


[PMID 23349498OA-icon.png] Link between GIP and osteopontin in adipose tissue and insulin resistance.