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rs10455872

From SNPedia

Orientationplus
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Geno Mag Summary
(A;A) 0 common/normal
(A;G) 2 1,51x increased Coronary Heart disease risk
(G;G) 3 2,57x increased Coronary Heart disease risk
ReferenceGRCh38 38.1/141
Chromosome6
Position160589086
GeneLPA
is asnp
is mentioned by
dbSNPrs10455872
ebirs10455872
HLIrs10455872
Exacrs10455872
Varsomers10455872
Maprs10455872
PheGenIrs10455872
hapmaprs10455872
1000 genomesrs10455872
hgdprs10455872
ensemblrs10455872
gopubmedrs10455872
geneviewrs10455872
scholarrs10455872
googlers10455872
pharmgkbrs10455872
gwascentralrs10455872
openSNPrs10455872
23andMers10455872
23andMe allrs10455872
SNP Nexus

SNPshotrs10455872
SNPdbers10455872
MSV3drs10455872
GWAS Ctlgrs10455872
GMAF0.03122
Max Magnitude3
? (A;A) (A;G) (G;G) 28

[PMID 20032323] Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease rs10455872, was associated with about 1.5-fold increased risk of Coronary Heart Disease. celera


[PMID 20160194] Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European Caucasians

[PMID 20605575] Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus

OMIM152200
Desc
Variant
Relatedalso
[PMID 21900290OA-icon.png] Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes


[PMID 22368281OA-icon.png] Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: Importance of Lp(a).

GWAS snp
PMID [PMID 22331829]
Trait
Title Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.
Risk Allele
P-val 5E-15
Odds Ratio 6.8000 None

[PMID 21127300OA-icon.png] Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk.

[PMID 21252144] Lipoprotein(a) genetic variants associated with coronary and peripheral vascular disease but not with stroke risk in the Heart Protection Study.

[PMID 21283670OA-icon.png] Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans.

[PMID 21305047OA-icon.png] Variation in LPA is associated with Lp(a) levels in three populations from the Third National Health and Nutrition Examination Survey.

[PMID 22560621] Cost-effectiveness model of use of genetic testing as an aid in assessing the likely benefit of aspirin therapy for primary prevention of cardiovascular disease.

GWAS snp
PMID [PMID 23118302]
Trait Lipoprotein-associated phospholipase A2 activity change in response to statin therapy
Title Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
Risk Allele G
P-val 2E-16
Odds Ratio 4.80 [0.82-2.78] percent increase


[PMID 23735648] Validation and Quantification of Genetic Determinants of Lipoprotein-a Levels and Predictive Value for Angiographic Coronary Artery Disease


[PMID 23978127OA-icon.png] Lack of association between lipoprotein(a) genetic variants and subsequent cardiovascular events in Chinese Han patients with coronary artery disease after percutaneous coronary intervention


[PMID 24161338] Elevated Lipoprotein(a) and Risk of Aortic Valve Stenosis in the General Population

GWAS snp
PMID [PMID 23388002OA-icon.png]
Trait Aortic-valve calcification
Title Genetic associations with valvular calcification and aortic stenosis.
Risk Allele G
P-val 3E-11
Odds Ratio 2.05 [1.66-2.53]


[PMID 24622370] Lipoprotein(a) concentrations, isoform size, and risk of type 2 diabetes: a Mendelian randomisation study


[PMID 22898070] Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism.


[PMID 23100282OA-icon.png] Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.


[PMID 23278389] Two rare variants explain association with acute myocardial infarction in an extended genomic region including the apolipoprotein(A) gene.


[PMID 23375930] Extreme lipoprotein(a) levels and improved cardiovascular risk prediction.


[PMID 24776095OA-icon.png] LPA rs10455872 polymorphism is associated with coronary lesions in Brazilian patients submitted to coronary angiography


[PMID 24903972] Genetic predisposition to calcific aortic stenosis and mitral annular calcification

GWAS snp
PMID [PMID 24262325OA-icon.png]
Trait Coronary artery disease or ischemic stroke
Title Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
Risk Allele
P-val 2E-12
Odds Ratio NR NR


[PMID 24760552OA-icon.png] Lipoprotein (a) concentrations, apolipoprotein (a) phenotypes, and peripheral arterial disease in three independent cohorts


[PMID 26564469] Advances in the Association between Apolipoprotein(a)Gene Polymorphisms and Coronary Heart Disease


ClinVar
Risk rs10455872(G;G)
Alt rs10455872(G;G)
Reference rs10455872(A;A)
Significance Drug-response
Disease hmg coa reductase inhibitors response - Efficacy
Variation info
Gene LPA
CLNDBN hmg coa reductase inhibitors response - Efficacy
Reversed 0
HGVS NC_000006.11:g.161010118A>G
CLNSRC PharmGKB Clinical Annotation PharmGKB
CLNACC RCV000211156.1,



[PMID 27831500] The LPA Gene, Ethnicity, and Cardiovascular Events.