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rs1045642(C;C)

From SNPedia

increased risk of cannabis dependence, lower (normal) cancer risk
Is agenotype
ofrs1045642
GeneABCB1
Chromosome7
Position87,509,329
mentionedby
Magnitude1
Geno Mag Summary
(C;C) 1 increased risk of cannabis dependence, lower (normal) cancer risk
(C;T) 2 Slower metaboliser for some drugs
(T;T) 3 altered drug metabolism and bioavailability; moderately increased risk for certain cancers


Association between ABCB1 C3435T polymorphism and increased risk of cannabis dependence. (2009). [1] Patients with cannabis dependence (n=40) had a significantly higher 3435C allele frequency (62.5% versus 43.8% respectively, P=0.017) and CC genotype (50% versus 20%, P=0.005, OR=4.00 [1.50-10.60]). The CC genotype was independently associated with cannabis dependence. This is the first time a significant specific genetic marker has been shown in cannabis dependence. ABCB1 polymorphisms may alter Delta9THC distribution, its psychoactive effects and individual vulnerability to dependence.