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rs10468017

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;T) 2 associated with higher HDL cholesterol
(T;T) 2 associated with higher HDL cholesterol


Make rs10468017(C;C)
ReferenceGRCh38 38.1/141
Chromosome15
Position58386313
GeneLOC102724766
is asnp
is mentioned by
dbSNPrs10468017
ebirs10468017
HLIrs10468017
Exacrs10468017
Varsomers10468017
Maprs10468017
PheGenIrs10468017
hapmaprs10468017
1000 genomesrs10468017
hgdprs10468017
ensemblrs10468017
gopubmedrs10468017
geneviewrs10468017
scholarrs10468017
googlers10468017
pharmgkbrs10468017
gwascentralrs10468017
openSNPrs10468017
23andMers10468017
23andMe allrs10468017
SNP Nexus

SNPshotrs10468017
SNPdbers10468017
MSV3drs10468017
GWAS Ctlgrs10468017
GMAF0.2094
Max Magnitude2
? (C;C) (C;T) (T;T) 28
GWAS snp
PMID [PMID 19060906OA-icon.png]
Trait HDL cholesterol
Title Common variants at 30 loci contribute to polygenic dyslipidemia
Risk Allele T
P-val 8E-23
Odds Ratio 0.10 [0.06-0.14] SD increase

T allele is associated with 1.76mg/dl increase in HDL cholesterol (good cholesterol). [PMID 18193043]



[PMID 20385826OA-icon.png] Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)

[PMID 21139980OA-icon.png] Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration

GWAS snp
PMID [PMID 21386085OA-icon.png]
Trait
Title A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium
Risk Allele C
P-val 6E-8
Odds Ratio 0.1600 [0.10-0.22] unit increase
GWAS snp
PMID [PMID 21665990OA-icon.png]
Trait
Title Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
Risk Allele
P-val 3E-12
Odds Ratio 1.1900 [NR]


[PMID 22247473OA-icon.png] Prospective Assessment of Genetic Effects on Progression to Different Stages of Age-related Macular Degeneration Using Multi-state Markov Models

GWAS snp
PMID [PMID 21943158OA-icon.png]
Trait
Title Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
Risk Allele T
P-val 3E-12
Odds Ratio 0.1040 [0.075-0.133] mmol/l increase
GWAS snp
PMID [PMID 22359512OA-icon.png]
Trait
Title Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
Risk Allele
P-val 7E-43
Odds Ratio 0 None


[PMID 19951432OA-icon.png] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.


[PMID 20160193OA-icon.png] Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.


[PMID 20385819OA-icon.png] Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.


GET Evidence
rs10468017
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.195312
summary



[PMID 24223199OA-icon.png] Association of HDL-Related Loci with Age-Related Macular Degeneration and Plasma Lutein and Zeaxanthin: the Alienor Study


[PMID 22692312] [Mendelian randomization study of the relationship between high-density lipoprotein cholesterol and age-related macular degeneration].


[PMID 23348725OA-icon.png] Association of LIPC and advanced age-related macular degeneration.


[PMID 25010633] The Relationship Between Hepatic Lipase Gene Variant and Advanced Age-Related Macular Degeneration: A Meta-analysis

GWAS snp
PMID [PMID 24816252OA-icon.png]
Trait Blood metabolite levels
Title An atlas of genetic influences on human blood metabolites.
Risk Allele T
P-val 3E-12
Odds Ratio .02 [0.013-0.025] unit increase


[PMID 27099955] Single-Nucleotide Polymorphisms Associated With Age-Related Macular Degeneration and Lesion Phenotypes in the Comparison of Age-Related Macular Degeneration Treatments Trials.