Have questions? Visit https://www.reddit.com/r/SNPedia

rs10484554

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 common
(C;T) 2.5 2.8x increased risk for psoriasis
(T;T) 2.5 ~4x increased risk for psoriasis
ReferenceGRCh38 38.1/141
Chromosome6
Position31306778
is asnp
is mentioned by
dbSNPrs10484554
ebirs10484554
HLIrs10484554
Exacrs10484554
Varsomers10484554
Maprs10484554
PheGenIrs10484554
hapmaprs10484554
1000 genomesrs10484554
hgdprs10484554
ensemblrs10484554
gopubmedrs10484554
geneviewrs10484554
scholarrs10484554
googlers10484554
pharmgkbrs10484554
gwascentralrs10484554
openSNPrs10484554
23andMers10484554
23andMe allrs10484554
SNP Nexus

SNPshotrs10484554
SNPdbers10484554
MSV3drs10484554
GWAS Ctlgrs10484554
GMAF0.1074
Max Magnitude2.5
? (C;C) (C;T) (T;T) 28
[PMID 18369459OA-icon.png] rs10484554 was the most highly significant SNP associated with risk for psoriasis in a large US/UK study.

[PMID 24270849OA-icon.png] rs10484554 was found to be associated with psoriasis based on a study by the eMERGE network in which electronic medical records were searched to find what clinical associations were associated with selected SNPs.

Neighborrs9264942
Distance175
GWAS snp
PMID [PMID 19115949]
Trait AIDS progression
Title Genomewide Association Study of an AIDS-Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02).
Risk Allele T
P-val 6E-8
Odds Ratio NR NR


OMIM604676
DescHLA COMPLEX P5 GENE; HCP5
Variant
Relatedalso
GWAS snp
PMID [PMID 20953190OA-icon.png]
Trait
Title A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
Risk Allele
P-val 0
Odds Ratio 4.6600 [4.23-5.13]

[PMID 19107206OA-icon.png] Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study.

[PMID 19182814OA-icon.png] New insights into the pathogenesis and genetics of psoriatic arthritis.

[PMID 19569043OA-icon.png] Genome-wide association studies and the genetic dissection of complex traits.

[PMID 21221856OA-icon.png] The search for host genetic factors of HIV/AIDS pathogenesis in the post-genome era: progress to date and new avenues for discovery.

[PMID 21253569OA-icon.png] Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations?

[PMID 21304891OA-icon.png] A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci.

[PMID 22474614OA-icon.png] Host Genes Important to HIV Replication and Evolution.


GET Evidence
rs10484554
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.105263
summary



[PMID 24566686] Human leukocyte antigen (HLA)-C polymorphisms are associated with a decreased risk of rheumatoid arthritis


[PMID 22931917OA-icon.png] Genetic association with ERAP1 in psoriasis is confined to disease onset after puberty and not dependent on HLA-C*06.


[PMID 27073425] Candidate gene polymorphisms and risk of psoriasis: A pilot study