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rs10485057

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal
(A;G) normal?
(G;G) 3 increased risk for smoking, nicotine dependence
ReferenceGRCh38 38.1/141
Chromosome6
Position154092120
GeneOPRM1
is asnp
is mentioned by
dbSNPrs10485057
ebirs10485057
HLIrs10485057
Exacrs10485057
Varsomers10485057
Maprs10485057
PheGenIrs10485057
hapmaprs10485057
1000 genomesrs10485057
hgdprs10485057
ensemblrs10485057
gopubmedrs10485057
geneviewrs10485057
scholarrs10485057
googlers10485057
pharmgkbrs10485057
gwascentralrs10485057
openSNPrs10485057
23andMers10485057
23andMe allrs10485057
SNP Nexus

SNPshotrs10485057
SNPdbers10485057
MSV3drs10485057
GWAS Ctlgrs10485057
GMAF0.09917
Max Magnitude3
? (A;A) (A;G) (G;G) 28
rs10485057 is a SNP in the opioid receptor, mu 1 OPRM1 gene.

A study of 688 Caucasian smokers (and non-smoking controls) indicated that the rare rs10485057(G) allele was associated with higher likelihood of smoking initiation and nicotine dependence. [PMID 16887046OA-icon.png]


[PMID 24766998OA-icon.png] Effect of OPRM1 and stressful life events on symptoms of major depression in African American adolescents


[PMID 26042510OA-icon.png] Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population