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rs10489629

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0.83x lower risk for spondylitis
(A;G) 0.83x lower risk for spondylitis
(G;G) normal risk
ReferenceGRCh38 38.1/141
Chromosome1
Position67222666
GeneIL23R
is asnp
is mentioned by
dbSNPrs10489629
ebirs10489629
HLIrs10489629
Exacrs10489629
Varsomers10489629
Maprs10489629
PheGenIrs10489629
hapmaprs10489629
1000 genomesrs10489629
hgdprs10489629
ensemblrs10489629
gopubmedrs10489629
geneviewrs10489629
scholarrs10489629
googlers10489629
pharmgkbrs10489629
gwascentralrs10489629
openSNPrs10489629
23andMers10489629
23andMe allrs10489629
SNP Nexus

SNPshotrs10489629
SNPdbers10489629
MSV3drs10489629
GWAS Ctlgrs10489629
GMAF0.4472
Max Magnitude
? (A;A) (A;G) (G;G) 28
rs10489629 is one of several SNPs in the IL23R gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with ankylosing spondylitis. The odds ratio is 0.83 (p=0.00014).[PMID 17952073, PMID 18037607]


[PMID 19034457] Lack of association between interleukin 23 receptor gene polymorphisms and rheumatoid arthritis susceptibility


[PMID 22089529] Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis


[PMID 22440928OA-icon.png] Perianal Crohn's Disease: Predictive Factors and Genotype-Phenotype Correlations


[PMID 17068223OA-icon.png] A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.


[PMID 17678723] Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort.


[PMID 17786191OA-icon.png] rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.


[PMID 18047539] Association between genetic variants in the IL-23R gene and early-onset Crohn's disease: results from a case-control and family-based study among Canadian children.


[PMID 18383363] Association of interleukin-23 receptor variants with ankylosing spondylitis.


[PMID 19175939OA-icon.png] IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease.


[PMID 19306001] No association between interleukin 23 receptor gene polymorphisms and systemic lupus erythematosus.


[PMID 19522770] Variants of the IL23R gene are associated with ankylosing spondylitis but not with Sjogren syndrome in Hungarian population samples.


[PMID 19757086] Interleukin-23 receptor gene variants in Hungarian systemic lupus erythematosus patients.


[PMID 19918037OA-icon.png] Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis.


[PMID 20454450OA-icon.png] Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.


[PMID 21253733] Interleukin-23 receptor genetic polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.


[PMID 22718508] Association of interleukin 23 receptor gene polymorphisms (rs10489629, rs7517847) with rheumatoid arthritis in European population: a meta-analysis.


[PMID 23053963] Associations between interleukin-23 receptor polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.