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rs1049353

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0 normal
(A;G) more resistant to treatment for depression
(G;G) more resistant to treatment for depression
(T;T) 0
ReferenceGRCh38 38.1/142
Chromosome6
Position88143916
GeneCNR1
is asnp
is mentioned by
dbSNPrs1049353
ebirs1049353
HLIrs1049353
Exacrs1049353
Varsomers1049353
Maprs1049353
PheGenIrs1049353
hapmaprs1049353
1000 genomesrs1049353
hgdprs1049353
ensemblrs1049353
gopubmedrs1049353
geneviewrs1049353
scholarrs1049353
googlers1049353
pharmgkbrs1049353
gwascentralrs1049353
openSNPrs1049353
23andMers1049353
23andMe allrs1049353
SNP Nexus

SNPshotrs1049353
SNPdbers1049353
MSV3drs1049353
GWAS Ctlgrs1049353
GMAF0.1373
Max Magnitude0
? (A;A) (A;G) (G;G) 28

Based on a study of 256 Caucasian patients being treated for depression, carriers of a rs1049353(G) allele were less likely to respond favorably, particularly if they were females with comorbid anxiety.[PMID 18579347]


[PMID 19443135OA-icon.png] The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults


[PMID 20195480OA-icon.png] The Cannabinoid 1 Receptor (CNR1) 1359 G/A Polymorphism Modulates Susceptibility to Ulcerative Colitis and the Phenotype in Crohn's Disease

rs806368(C) together with rs1049353(A) or rs1049353(G) make up a haplotype associated with PTSD, with the C-A haplotype somewhat associated (p=0.04) with higher risk of PTSD and the C-G haplotype associated (p=0.01) with a lower risk of PTSD. [PMID 18213623OA-icon.png]


[PMID 20587580] Polymorphisms in the endocannabinoid-receptor 1 in relation to fat mass distribution


[PMID 21892520] The association of the rs1049353 polymorphism of the CNR1 gene with hypoadiponectinemia


[PMID 22085192] Cannabinoid Receptor 1 Gene is Associated with Alcohol Dependence

[PMID 16917946OA-icon.png] Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents.

[PMID 17292652] No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents.

[PMID 17873324] The G1422A variant of the cannabinoid receptor gene (CNR1) is associated with abdominal adiposity in obese men.

[PMID 17881126] No association of CNR1 gene variations with susceptibility to schizophrenia.

[PMID 17942526] Polymorphisms of the cannabinoid 1 receptor gene and cognitive impairment in multiple sclerosis.

[PMID 18179391] Association between single nucleotide polymorphisms in the cannabinoid receptor gene (CNR1) and impulsivity in southwest California Indians.

[PMID 18606954OA-icon.png] Cannabinoid receptor 1 gene association with nicotine dependence.

[PMID 18776593OA-icon.png] Cannabinoid type-1 receptor gene polymorphisms are associated with central obesity in a Southern Brazilian population.

[PMID 19014633OA-icon.png] Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa.

[PMID 19016476OA-icon.png] Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.

[PMID 19018721OA-icon.png] Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index.

[PMID 19052543OA-icon.png] Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample.

[PMID 19093002OA-icon.png] CB1 expression is attenuated in Fallopian tube and decidua of women with ectopic pregnancy.

[PMID 19335651OA-icon.png] Candidate genes for cannabis use disorders: findings, challenges and directions.

[PMID 19659925] Association of CNR1 and FAAH endocannabinoid gene polymorphisms with anorexia nervosa and bulimia nervosa: evidence for synergistic effects.

[PMID 19886064] The implication of CNR1 gene's polymorphisms in the modulation of endocannabinoid system effects.

[PMID 20033240OA-icon.png] Eating disorders: the current status of molecular genetic research.

[PMID 20080186] Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression.

[PMID 20192949] CNR1 gene polymorphisms in addictive disorders: a systematic review and a meta-analysis.

[PMID 20204253] G1359A polymorphism of the cannabinoid receptor gene (CNR1) and insulin resistance in patients with diabetes mellitus type 2.

[PMID 20415562] Role of genetic variation in the cannabinoid type 1 receptor gene (CNR1) in the pathophysiology of human obesity.

[PMID 20631561] Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain.

[PMID 20838400] Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with obesity and metabolic syndrome in postmenopausal Polish women?

[PMID 21129839] A common variation in the cannabinoid 1 receptor (CNR1) gene is associated with pre-eclampsia in the Central European population.

[PMID 21695734] Cannabinoid type 1 receptor gene polymorphisms are not associated with olanzapine-induced weight gain.

[PMID 22393204OA-icon.png] Cannabinoid Receptor Genotype Moderation of the Effects of Childhood Physical Abuse on Anhedonia and Depression.


[PMID 22194214] Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes


[PMID 22826533] Genetic variability in the endocannabinoid system and 12-week clinical response to citalopram treatment: the role of the CNR1, CNR2 and FAAH genes


[PMID 23372171] Elevated Anandamide and Related N-Acylethanolamine Levels Occur in the Peripheral Blood of Women With Ectopic Pregnancy and Are Mirrored by Changes in Peripheral Fatty Acid Amide Hydrolase Activity


[PMID 24322329] Role of Genetic Variation in the Cannabinoid Receptor Gene (CNR1) (G1359A Polymorphism) on Weight Loss and Cardiovascular Risk Factors After Liraglutide Treatment in Obese Patients With Diabetes Mellitus Type 2


[PMID 24407958] Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures


[PMID 22920733] Investigation of endocannabinoid system genes suggests association between peroxisome proliferator activator receptor-alpha gene (PPARA) and schizophrenia.


[PMID 23010766OA-icon.png] Failure to extinguish fear and genetic variability in the human cannabinoid receptor 1.


[PMID 23337343] Genetic variation in the cannabinoid receptor gene (CNR1) (G1359A polymorphism) and their influence on anthropometric parameters and metabolic parameters under a high monounsaturated vs. high polyunsaturated fat hypocaloric diets.


[PMID 23407780] Screening genetic variability at the CNR1 gene in both major depression etiology and clinical response to citalopram treatment.


[PMID 23422373] CNR1 gene and risk of the metabolic syndrome in patients with schizophrenia.


[PMID 25093427] Selected CNR1 polymorphisms and hyperandrogenemia as well as fat mass and fat distribution in women with polycystic ovary syndrome


[PMID 25136364OA-icon.png] Cannabinoid receptor 1 gene polymorphisms and nonalcoholic Fatty liver disease in women with polycystic ovary syndrome and in healthy controls


[PMID 25766592] Effects of a High-Protein/Low-Carbohydrate versus a Standard Hypocaloric Diet on Weight and Cardiovascular Risk Factors during 9 Months: Role of a Genetic Variation in the Cannabinoid Receptor Gene (CNR1) (G1359A Polymorphism)


[PMID 26071625] Brain structural and clinical changes after first episode psychosis: Focus on cannabinoid receptor 1 polymorphisms


[PMID 24980155] Role of CNR1 polymorphisms in moderating the effects of psychosocial adversity on impulsivity in adolescents