rs10495584
From SNPedia
| blood pressure in men |
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 1.1 | Normal (higher) blood pressure. |
| (A;G) | 2 | Lowers men's blood pressure by -6.3/-3.8 mm Hg. |
| (G;G) | 2.5 | Lowers men's blood pressure by -6.3/-3.8 mm Hg. |
| Reference | GRCh38 38.1/141 |
| Chromosome | 2 |
| Position | 11819857 |
| Gene | LPIN1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10495584 |
| dbSNP (classic) | rs10495584 |
| ClinGen | rs10495584 |
| ebi | rs10495584 |
| HLI | rs10495584 |
| Exac | rs10495584 |
| Gnomad | rs10495584 |
| Varsome | rs10495584 |
| LitVar | rs10495584 |
| Map | rs10495584 |
| PheGenI | rs10495584 |
| Biobank | rs10495584 |
| 1000 genomes | rs10495584 |
| hgdp | rs10495584 |
| ensembl | rs10495584 |
| geneview | rs10495584 |
| scholar | rs10495584 |
| rs10495584 | |
| pharmgkb | rs10495584 |
| gwascentral | rs10495584 |
| openSNP | rs10495584 |
| 23andMe | rs10495584 |
| SNPshot | rs10495584 |
| SNPdbe | rs10495584 |
| MSV3d | rs10495584 |
| GWAS Ctlg | rs10495584 |
| GMAF | 0.08402 |
| Max Magnitude | 2.5 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
The minor (G) allele of SNP rs10495584 was associated with lower mean systolic and diastolic blood pressures in men (121.1 +/- 14.2 and 76.3 +/- 10.2 mm Hg vs. 127.4 +/- 15.2 and 80.1 +/- 10.5 mm Hg, P = 0.002 and 0.007, respectively), but not in women (P > 0.05), and remained significant after correction for numerous other factors. However, its effect may be caused by a nearby, tightly linked SNP, rs11524.[PMID 18437145]
