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rs10495584

From SNPedia

blood pressure in men
Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 1.1 Normal (higher) blood pressure.
(A;G) 2 Lowers men's blood pressure by -6.3/-3.8 mm Hg.
(G;G) 2.5 Lowers men's blood pressure by -6.3/-3.8 mm Hg.
ReferenceGRCh38 38.1/141
Chromosome2
Position11819857
GeneLPIN1
is asnp
is mentioned by
dbSNPrs10495584
ebirs10495584
HLIrs10495584
Exacrs10495584
Varsomers10495584
Maprs10495584
PheGenIrs10495584
hapmaprs10495584
1000 genomesrs10495584
hgdprs10495584
ensemblrs10495584
gopubmedrs10495584
geneviewrs10495584
scholarrs10495584
googlers10495584
pharmgkbrs10495584
gwascentralrs10495584
openSNPrs10495584
23andMers10495584
23andMe allrs10495584
SNP Nexus

SNPshotrs10495584
SNPdbers10495584
MSV3drs10495584
GWAS Ctlgrs10495584
GMAF0.08402
Max Magnitude2.5
? (A;A) (A;G) (G;G) 28

The minor (G) allele of SNP rs10495584 was associated with lower mean systolic and diastolic blood pressures in men (121.1 +/- 14.2 and 76.3 +/- 10.2 mm Hg vs. 127.4 +/- 15.2 and 80.1 +/- 10.5 mm Hg, P = 0.002 and 0.007, respectively), but not in women (P > 0.05), and remained significant after correction for numerous other factors. However, its effect may be caused by a nearby, tightly linked SNP, rs11524.[PMID 18437145]