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rs10498345

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) <0.5x decreased risk for coronary spasm
(A;T) 0.5x decreased risk for coronary spasm
(T;T) 0 normal
ReferenceGRCh38 38.1/141
Chromosome14
Position38551301
is asnp
is mentioned by
dbSNPrs10498345
ebirs10498345
HLIrs10498345
Exacrs10498345
Varsomers10498345
Maprs10498345
PheGenIrs10498345
hapmaprs10498345
1000 genomesrs10498345
hgdprs10498345
ensemblrs10498345
gopubmedrs10498345
geneviewrs10498345
scholarrs10498345
googlers10498345
pharmgkbrs10498345
gwascentralrs10498345
openSNPrs10498345
23andMers10498345
23andMe allrs10498345
SNP Nexus

SNPshotrs10498345
SNPdbers10498345
MSV3drs10498345
GWAS Ctlgrs10498345
GMAF0.112
Max Magnitude0
? (A;A) (A;T) (T;T) 28
rs10498345 is a SNP on chromosome 14 that has been associated with coronary spasm (often a precursor to various types of heart disease) in a study of Japanese women.

For unknown reasons, the prevalence of coronary spasm in higher in Japanese than in Caucasians. In this study of ~800 Japanese individuals, the ~200 women with coronary spasm were found to preferentially harbor the genotype with rs10498345(T), or to put it another way, the rs10498345(A) allele appears to be protective, with an odds ratio of 0.5 (p=3.5x10e-4). No association was seen in males.[PMID 18075462]

GWAS
SNP rs10498345
PubMedID [PMID 18075462]
Condition Coronary spasm in women
Gene Intergenic
Risk Allele T
pValue 9.00E-007
OR 2.33
95% CI 1.64-3.23



GET Evidence
rs10498345
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.101562
summary